Search for dissertations about: "rhabdomyosarcoma"
Showing result 6 - 10 of 13 swedish dissertations containing the word rhabdomyosarcoma.
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6. Mechanisms acting on Hedgehog-GLI pathway and their therapeutic potential
Abstract : Hedgehog signaling is crucial for diverse aspects of animal development, essential in regulating many cellular processes and is largely implicated in various forms of human cancer. However, many aspects of Hedgehog signaling are not completely understood. READ MORE
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7. Identification and validation of therapeutic targets in sarcoma models
Abstract : In spite of the low incidence of sarcomas, they are highly aggressive tumors, with high metastatic potential, and resistance to both chemotherapy and radiotherapy, leaving surgery as the only treatment option. There is evidently an urgent need in identifying molecular targets and oncogenic pathways in sarcomas that can be used for the development and evaluation of drugs directed against these tumors. READ MORE
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8. Activation of the novel PDGFS by plasminogen activators in tumorigenesis
Abstract : Members of the platelet-derived growth factor (PDGF) family are mitogens for cells of a mesenchymal origin and have important functions both during development and in the adult. Their role in developmental processes has been extensively investigated by methodical targeted gene inactivations, revealing critical involvement in microvascular pericyte recruitment, neural crest development and alveogenesis. READ MORE
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9. Mechanisms of hedgehog signaling activation in cancer development
Abstract : Hedgehog (HH) signaling has an important role in many physiological processes, and deregulation of this pathway can result in a wide range of malignancies. The aim of this thesis is to identify and evaluate the role of various posttranscriptional mechanisms, including alternative splicing, RNA editing and antisense RNAs, associated with different key components of HH signaling. READ MORE
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10. GLI1 modulation of the output of hedgehog signaling in human cancer
Abstract : The Hedgehog (HH) signaling pathway has critical roles in embryonic development and tumorigenesis. Aberrant activation of HH signaling has been known to be involved in several types of malignant tumors. GLI1 is a transcription factor that acts not only as the terminal effector but also represents a pathway target gene, amplifying the HH signal. READ MORE
