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Showing result 1 - 5 of 478 swedish dissertations matching the above criteria.

2. 1. Early rheumatoid arthritis : biomarkers and hormonal factors in relation to disease progression

   Author : Antonia Boman; Solbritt Rantapää-Dahlqvist; Ewa Berglin; Gerd-Marie Alenius; Mikael Brink; Heidi Kokkonen; Inger Gjertsson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Early rheumatoid arthritis; biomarker; ACPA; RANKL; disease activity; radiological destruction; cardiovascular events; hormonal factors; reumatologi; rheumatology;

   Abstract : Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, affecting approximately 0.5 to 1% of the adult population. Although the aetiology is not fully known, a complex interaction between genetic, environmental and stochastic factors is thought to trigger the pathogenic mechanisms. READ MORE

4. 2. Pharmacometric Modeling in Rheumatoid Arthritis

   Author : Brigitte Lacroix; Lena Friberg; Mats Karlsson; Maria Laura Sargentini-Maier; Kosmas Kretsos; Ekaterina Gibiansky; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; PKPD; immunogenicity; ACR; IPPSE; certolizumab pegol;

   Abstract : Biologic therapies have revolutionized the treatment of rheumatoid arthritis, a common chronic inflammatory disease, mainly characterized by the chronic inflammation of the joints. The activity and progression of the disease are highly variable, both between subjects and between the successive assessments for the same subject. READ MORE

5. 3. Genetic markers in rheumatoid arthritis

   Author : Solbritt Rantapää Dahlqvist; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; family history; genetic marker; HLA B27; HLA DR4; properdin factor B; C3 complement; -antitrypsin; haptoglobin; transferrin;

   Abstract : Genetic as well as environmental factors are believed to be of importance in the etiology of rheumatoid arthritis (RA). There are a number of previous studies of genetic markers in RA, but so far no genetic linkage and only a few associations have been found. Of the associations only one (with the HLA antigen DR4) appears to be well documented. READ MORE

6. 4. Disease activity in rheumatoid arthritis : Studies in interleukin-6, tumour necrosis factor alpha, monocyte activity, acute phase markers, glucocorticoids, and disability

   Author : Nils Gunnar Arvidson; Anders Larsson; Arvi Larsen; Øystein Førre; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; acute phase markers; circadian rhythm; disability; disease activity; glucocorticoids; monocyte activation; rheumatoid arthritis; Kemi; Chemistry; Kemi; Medicine; medicin;

   Abstract : In the present studies, aspects of some disease activity measures in rheumatoid arthritis (RA) have been investigated, including the effect of glucocorticoids on this activity. In RA, serum interleukin(IL)-6 levels were elevated and were shown to have a circadian rhythm, with peak levels in the morning, declining towards low or normal levels in the afternoon and evening. READ MORE

7. 5. Rho-GTPases in Rheumatoid Arthritis

   Author : Eric Malmhäll-Bah; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rho-GTPases; rheumatoid arthritis; innate immunity; adaptive immunity; RA treatment;

   Abstract : The success of alleviating rheumatoid arthritis (RA) symptoms is complicated by both heterogeneity of the disease and lack of predictive markers to guide treatment options. Deregulated Rho-GTPases, a family of hydrolase enzymes catalyzing guanosine triphospate (GTP) to guanosine diphospate (GDP), have a detrimental role in many diseases including RA. READ MORE