Search for dissertations about: "ribavirin."

Showing result 1 - 5 of 24 swedish dissertations containing the word ribavirin..

  2. 1. Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection

    Author : Jesper Waldenström; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C virus; HCV; Inosine triphosphate pyrophosphatase; ITPA; interferon-λ4; IFNL4; ribavirin; interferon; PWID; IP-10;

    Abstract : Hepatitis C virus (HCV) impacts on global health with around 70 million chronically infected worldwide. The infection increases the risk of cirrhosis and primary liver cancer. The treatment until 2013 has been based on interferon-α and ribavirin, but is now replaced by direct acting antivirals. READ MORE

  4. 2. Immunological and Genetic Markers Predicting Treatment Outcome in Hepatitits C Virus Infection

    Author : Galia Askarieh; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IP-10; CXCL10; CD26; hepatitis C virus; interferon; ribavirin; treatment; IL28B;

    Abstract : Hepatitis C is a blood-borne infection caused by the hepatitis C virus (HCV). A chronic infection, which develops in most infected subjects, may lead to liver cirrhosis with ensuing liver dysfunction and liver cancer. READ MORE

  5. 3. Ribavirin : dose and concentration in treatment of chronic hepatitis C infected patients

    Author : Karin Lindahl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hepatits C; ribavirin; pharmacokinetics; renal function; plasma concentration; anaemia; population pharmacokinetic analysis; peginterferon; sustained viral response;

    Abstract : Chronic hepatitis C infection is a global health problem with 170 million patients infected. Hepatitis C virus (HCV) infection is a leading cause of end stage liver disease. Current antiviral treatment options available are not optimal either regarding cure of disease or risk of side effects. READ MORE

  6. 4. Hepatitis C virus kinetics during antiviral treatment

    Author : Tony Carlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hepatitis C virus RNA; genotype; kinetics; interferon-alpha; ribavirin.;

    Abstract : It is estimated that 170 million individuals have chronic hepatitis C virus (HCV) infection, whereof 20-30% will develop end stage liver disease within 20-30 years. Antiviral therapy can stop this deterioration and clear the infection in 40-80% of the patients depending on treatment and HCV genotype. READ MORE

  7. 5. Hepatitis C in chronic kidney disease and kidney transplantation : with special reference to epidemiology and treatment

    Author : Annette Bruchfeld; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hepatitis C; kidney transplantation; patient and graft survival; renal replacement therapy; dialysis; renal insufficiency; interferon-alpha; ribavirin; plasma concentration; anaemia; population pharmacokinetics; renal function.;

    Abstract : Hepatitis C (HCV) is a clinical problem in infected kidney transplant patients but is also a cause of renal disease and vasculitis. Standard therapy for HCV is a combination of interferon and ribavirin. READ MORE