Search for dissertations about: "ribosome binding site"
Showing result 1 - 5 of 38 swedish dissertations containing the words ribosome binding site.
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1. Computational Studies of Protein Synthesis on the Ribosome and Ligand Binding to Riboswitches
Abstract : The ribosome is a macromolecular machine that produces proteins in all kingdoms of life. The proteins, in turn, control the biochemical processes within the cell. It is thus of extreme importance that the machine that makes the proteins works with high precision. READ MORE
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2. From Structure to Function with Binding Free Energy Calculations for Codon Reading, Riboswitches and Lectins
Abstract : Molecular association is part of many important processes in living cells. Computational methods for calculating binding free energies allows for a quantitative examination of biomolecular structures and hypotheses drawn from biochemical experiments. READ MORE
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3. Molecular Interplay of Antibiotics on the Bacterial Ribosome
Abstract : Inhibition of protein synthesis is one of the most common modes of action for medically useful antibiotics. This thesis presents the mechanistic studies of two chemically distinct classes of antibiotics that target bacterial ribosomes –aminoglycosides and thermorubin. READ MORE
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4. The ribosome, stringent factor and the bacterial stringent response
Abstract : The stringent response plays a significant role in the survival of bacteria during different environmental conditions. It is activated by the binding of stringent factor (SF) to stalled ribosomes that have an unacylated tRNA in the ribosomal A-site which leads to the synthesis of (p)ppGpp. READ MORE
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5. Protein Folding Activity of the Ribosome and Its Implication in Prion Processes
Abstract : How the linear protein chains fold into their three-dimensional active conformation is one of the remaining puzzles of modern science. Other than molecular chaperones, ribosome - the cellular protein synthesis machinery, has also been implicated in protein folding. READ MORE