Search for dissertations about: "ribosome"
Showing result 6 - 10 of 182 swedish dissertations containing the word ribosome.
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6. Molecular Interplay of Antibiotics on the Bacterial Ribosome
Abstract : Inhibition of protein synthesis is one of the most common modes of action for medically useful antibiotics. This thesis presents the mechanistic studies of two chemically distinct classes of antibiotics that target bacterial ribosomes –aminoglycosides and thermorubin. READ MORE
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7. High-resolution phenotypic profiling of a eukaryotic ribosome
Abstract : All living cells contain ribosomes, complex macromolecular assemblies of ribonucleic acid (RNA) and proteins, responsible for synthesizing polypeptides in a process called translation. High-resolution three-dimensional ribosomal structures coupled with biochemical studies have paved the way in understanding the various mechanistic events during protein synthesis. READ MORE
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8. On the Origin and Evolution of the Mitochondrial Ribosome
Abstract : The ribosome is among the most ancient, intricate and well studied macromolecular complexes in biology. Predating the earliest divergence of life, its core molecular structure has remained mostly unchanged for more than three billion years. READ MORE
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9. The ribosome, stringent factor and the bacterial stringent response
Abstract : The stringent response plays a significant role in the survival of bacteria during different environmental conditions. It is activated by the binding of stringent factor (SF) to stalled ribosomes that have an unacylated tRNA in the ribosomal A-site which leads to the synthesis of (p)ppGpp. READ MORE
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10. Protein Folding Activity of the Ribosome and Its Implication in Prion Processes
Abstract : How the linear protein chains fold into their three-dimensional active conformation is one of the remaining puzzles of modern science. Other than molecular chaperones, ribosome - the cellular protein synthesis machinery, has also been implicated in protein folding. READ MORE