Search for dissertations about: "rickettsia prowazekii"

Showing result 1 - 5 of 6 swedish dissertations containing the words rickettsia prowazekii.

2. 1. Mapping the Rickettsia prowazekii genome

   Author : Alireza Zomorodipour; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Abstract : Rickettsia prowazekii is a member of alpha proteobacteria and the etiologic agent of epidemictyphus. Besides its pathogenicity as an obligate intracellular parasite it has been considered as amodel organism in a variety of studies.We have established a collection of overlapping clones, covering nearly the complete R.prowazekii genome. READ MORE

4. 2. Causes of Substitution Frequency Variation in Pathogenic Bacteria

   Author : Wagied Davids; Siv Andersson; Otto Berg; Bengt Persson; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; Comparative genomics; Molecular evolution; Bioinformatics; Human pathogens; Rickettsia; Helicobacter pylori; Biologi; Biology; Biologi;

   Abstract : Estimating substitution frequencies at sites that influence (Ka) and do not influence (Ks) the amino acid sequence is important for understanding the dynamics of molecular sequence evolution and the selective pressures that have shaped genetic variation. The aim of this work was to gain a deeper understanding of the driving forces of substitution frequency variation in human pathogens. READ MORE

5. 3. Molecular evolutionary studies of genome degradation in bacteria

   Author : Jan O. Andersson; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

   Abstract : The genus Rickettsia belongs to the α-proteobacteria and consists of obligate intracellular bacteria, which often are pathogenic for humans. All Rickettsia have small genomes, highly adapted to an intracellular lifestyle. READ MORE

6. 4. Comparative Genomics of Obligate and Facultative Intracellular Parasites

   Author : Cecilia Alsmark; Russell Regnery; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

   Abstract : The α-proteobacteria Rickettsia prowazekii and Bartonella henselae are the causative agents of epidemic typhus and cat scratch disease respectively. Whereas R. prowazekii is an obligate intracellular parasite, B. henselae can live and proliferate both outside and inside the eukaryotic host cell. READ MORE

7. 5. Bioinformatic tools for the analysis of microbial genomes

   Author : Thomas Sicheritz-Pontén; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

   Abstract : High throughput genome sequencing projects are producing an enormous amount of rawdata which has to be converted into biological knowledge. The newly established field ofbioinformatics is concerned with the continuous development of novel methods and toolsfor the comparative analysis of DNA sequences and genomic data. READ MORE