Search for dissertations about: "risperidone"

Showing result 1 - 5 of 16 swedish dissertations containing the word risperidone.

2. 1. PET applications in schizophrenia : Functional and pharmacological dopamine studies

   Author : Ola Gefvert; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Schizophrenia; PET; dopamine synthesis rate; dopamine D2 receptor occupancy; atypical antipsychotics; quetiapine; risperidone microsphere depot; Neurovetenskap; Neurology; Neurologi; Psychiatry; psykiatri;

   Abstract : Schizophrenia is a group of disorders with a worldwide lifetime prevalence of 0.85%. Thefunctional outcome of the disorder seem stable from the first systematic outcome studies to thepresent day, and vary only with changes in diagnostic criteria. READ MORE

4. 2. Cytochrome P450 2C9, 2C19 and 2D6 genetic polymorphisms : evaluation of genotyping as a tool for individualised treatment

   Author : Maria Gabriella Scordo; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Drug metabolism; CYP2C9; CYP2C19; CYP2D6; genotyping; polymorphism; risperidone; warfarin; fluoxetine; phenytoin; extrapyramidal side-effects;

   Abstract : Recent advances in the understanding of drug metabolism and the molecular biology of CYPs have generated great expectations regarding the use of pharmacogenetic testing as a tool to individualize drug treatment. The individual pharmacogenetic constitution might in principle predict the response to drugs, hormones and toxins. READ MORE

5. 3. Drug metabolic capacity in Koreans : CYP2D6 & CYP2C19 pheno- and genotype relationships in healthy volunteers and in patients

   Author : Hyung-Keun Roh; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Drug metabolism; phenotype; genotype; CYP2D6; CYP2C 19; Korean; haloperidol; risperidone; omeprazole; gastric pH; gastrin; schizophrenia; patient.;

   Abstract : This thesis aimed to investigate the relationship between pheno- and genotype of two drugmetabolizing enzymes CYP2D6 and CYYP2C19 in Koreans. Population studies were conducted in healthy volunteers to obtain basic information on these two enzymes. READ MORE

6. 4. On the mechanisms of action of atypical antipsychotic drugs : an experimental study

   Author : Peter Hertel; Karolinska Institutet; Karolinska Institutet; []
   Keywords : antipsychotic drugs; dopamine; serotonin; medial prefrontal cortex; dorsal raphe nucleus; risperidone; clozapine; idazoxan; [alpha]2 adrenoceptors; conditioned avoidance; catalepsy;

   Abstract : A majority of schizophrenic patients respond to classical neuroleptic drugs which are believed to act largely via blockade of dopamine (DA) D2 receptors in limbic structures. However, a significant proportion do not respond to conventional D2 receptor blocking drugs or show a rather incomplete therapeutic effect, particularly on negative and cognitive symptoms. READ MORE

7. 5. Using CSF biomarkers to understand mechanisms of behavioral changes and effects of drug treatment in dementia

   Author : Victor Bloniecki Kallio; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Dementia is affecting millions of people around the world, and the global prevalence will continuously rise. Neuropsychiatric symptoms (NPS) in dementia are frequent and constitute a key driving force in the disease burden for both patients, families, caregivers and society. READ MORE