Search for dissertations about: "rna seq"

Showing result 1 - 5 of 151 swedish dissertations containing the words rna seq.

  2. 1. Chromosome-specific adaptations of RNA stability and the roles of the roX RNAs in dosage compensation

    Author : Marie-Line Faucillion; Jan Larsson; Jean-Yves Roignant; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila melanogaster; dosage compensation; buffering; RNA stability; RNA decay; RNA half-life; RNA-seq; genome-wide; sex chromosomes; evolution; roX1; roX2; POF; MSL; molekylärbiologi; Molecular Biology;

    Abstract : Sex chromosomes evolved from an ancient pair of autosomes and the Y chromosome lost most of its genetic information in the process. This created two kinds of genomic imbalances: the first one between males (XY) and females (XX) and the second one between the sex chromosomes and the autosomes (X:AA). READ MORE

  4. 2. Computational methods for analysis and visualization of spatially resolved transcriptomes

    Author : Jose Fernandez Navarro; Joakim Lundeberg; Martin Hemberg; KTH; []
    Keywords : RNA; RNA-seq; single cell; scRNA-seq; transcriptomics; spatial transcriptomics; brain; 3D; Alzheimer’s disease; Bioteknologi; Biotechnology;

    Abstract : Characterizing the expression level of genes (transcriptome) in cells and tis- sues is essential for understanding the biological processes of multicellular or- ganisms. RNA sequencing (RNA-seq) has gained traction in the last decade as a powerful tool that provides an accurate quantitative representation of the transcriptome in tissues. READ MORE

  5. 3. On Transcriptome Sequencing

    Author : Daniel Klevebring; Joakim Lundeberg; Ulf Gyllensten; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transcriptome; RNA-seq; DNA sequencing; gene expression profiling; non-coding RNA; small RNA; Functional genomics; Funktionsgenomik; Bioinformatics; Bioinformatik; Genetics; Genetik; Molecular biology; Molekylärbiologi; Cell biology; Cellbiologi;

    Abstract : This thesis is about the use of massive DNA sequencing to investigate the transcriptome. During recent decades, several studies have made it clear that the transcriptome comprises a more complex set of biochemical machinery than was previously believed. READ MORE

  6. 4. Data Analysis and Next Generation Sequencing : Applications in Microbiology

    Author : Nicolas Innocenti; Erik Aurell; Mogens Jensen; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; RNA-seq; tagRNA-seq; primary and processed RNA; Enterococcus faecalis; Complex transcription; Metagenomics; 5 tagRACE; minimal absent words; compressed sensing; metagenomics; bacterial community reconstruction; Biologisk fysik; Biological Physics;

    Abstract : Next Generation Sequencing (NGS) is a new technology that has revolutionized the way we study living organisms. Where previously only a few genes could be studied at a time through targeted direct probing, NGS offers the possibility to perform measurements for a whole genome at once. READ MORE

  7. 5. A-to-I RNA editing : Function and consequences during brain development

    Author : Ylva Ekdahl; Marie Öhman; Kazuko Nishikura; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNA editing; miRNAs; Brain development; Molecular Biology; molekylärbiologi;

    Abstract : The aim of my thesis has been to study how A-to-I RNA editing of miRNAs is regulated during brain development and the biological function of these editing events.Using high throughput RNA sequencing, we performed an unbiased search for edited, mature miRNAs in total mouse brain tissue from three developmental stages. READ MORE