Search for dissertations about: "roX"

Found 4 swedish dissertations containing the word roX.

  1. 1. Aneuploidy compensatory mechanisms and genome-wide regulation of gene expression in Drosophila melanogaster

    University dissertation from Umeå : Umeå Universitet

    Author : Lina Lundberg; Umeå universitet.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Genome-wide gene regulation; aneuploidy; buffering; HP1a; POF; SETDB1; Su var 3-9; MSL; roX; genetik; Genetics;

    Abstract : Stimulation or repression of gene expression by genome-wide regulatory mechanisms is an important epigenetic regulatory function which can act to efficiently regulate larger regions or specific groups of genes, for example by compensating for loss or gain of chromosome copy numbers. In Drosophila melanogaster there are two known chromosome-wide regulatory systems; the MSL complex, which mediates dosage compensation of the single male X-chromosome and POF, which stimulates expression from the heterochromatic 4th chromosome. READ MORE

  2. 2. Mining DNA elements involved in targeting of chromatin modifiers

    University dissertation from Umeå : Umeå University

    Author : Philge Philip; Umeå universitet.; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nucleosome; histone; chromatin; chromatin modifiers; targeting; DNA motifs; protein factors; MSL; molekylärbiologi; Molecular Biology;

    Abstract : Background: In all higher organisms, the nuclear DNA is condensed into nucleosomes that consist of DNA wrapped around a core of highly conserved histone proteins. DNA bound to histones and other structural proteins form the chromatin. READ MORE

  3. 3. bHLH transcription factors in differentiating neuroblastoma cells

    University dissertation from Anna Grynfeld, Jumkilsg 18B, 752 18 Uppsala, Sweden

    Author : Anna Grynfeld; Lund University.; Lunds universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bHLH; Neuroblastoma; HES-1; HASH-1; N-Myc; differentiation; Mad; Medicine human and vertebrates ; Medicin människa och djur ;

    Abstract : Neuroblastoma is a tumor of the sympathetic nervous system, and arises during early childhood. The tumor is highly heterogeneous and evidence, such as expression of genes normally only expressed during embryonic and fetal stages, suggests that the tumor is of embryonic origin and that the tumor arises as a consequence of perturbed differentiation during the development of the sympathetic nervous system. READ MORE

  4. 4. Chromosome-wide gene regulatory mechanisms in Drosophila melanogaster

    University dissertation from Umeå : Arkitektkopia

    Author : Anna-Mia Johansson; Umeå universitet.; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chromatin structure; Drosophila; POF; disage compensation; gene expression; MSL; heterochromatin; NATURAL SCIENCES Biology Cell and molecular biology Genetics; NATURVETENSKAP Biologi Cell- och molekylärbiologi Genetik; genetik; Genetics;

    Abstract : In Drosophila there are two different chromosome-wide targeting systems, the dosage compensation system that equalizes the transcriptional output from X-linked genes between males and females, and the regulation of the 4th chromosome mediated by the POF protein.   The best studied of these two mechanisms is the dosage compensation system. READ MORE