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Showing result 1 - 5 of 7 swedish dissertations matching the above criteria.

  2. 1. Aneuploidy compensatory mechanisms and genome-wide regulation of gene expression in Drosophila melanogaster

    Author : Lina Lundberg; Jan Larsson; Brian Oliver; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Genome-wide gene regulation; aneuploidy; buffering; HP1a; POF; SETDB1; Su var 3-9; MSL; roX; genetik; Genetics;

    Abstract : Stimulation or repression of gene expression by genome-wide regulatory mechanisms is an important epigenetic regulatory function which can act to efficiently regulate larger regions or specific groups of genes, for example by compensating for loss or gain of chromosome copy numbers. In Drosophila melanogaster there are two known chromosome-wide regulatory systems; the MSL complex, which mediates dosage compensation of the single male X-chromosome and POF, which stimulates expression from the heterochromatic 4th chromosome. READ MORE

  4. 2. Chromosome-specific adaptations of RNA stability and the roles of the roX RNAs in dosage compensation

    Author : Marie-Line Faucillion; Jan Larsson; Jean-Yves Roignant; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila melanogaster; dosage compensation; buffering; RNA stability; RNA decay; RNA half-life; RNA-seq; genome-wide; sex chromosomes; evolution; roX1; roX2; POF; MSL; molekylärbiologi; Molecular Biology;

    Abstract : Sex chromosomes evolved from an ancient pair of autosomes and the Y chromosome lost most of its genetic information in the process. This created two kinds of genomic imbalances: the first one between males (XY) and females (XX) and the second one between the sex chromosomes and the autosomes (X:AA). READ MORE

  5. 3. Mining DNA elements involved in targeting of chromatin modifiers

    Author : Philge Philip; Per Stenberg; Jan Larsson; Stein Aerts; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nucleosome; histone; chromatin; chromatin modifiers; targeting; DNA motifs; protein factors; MSL; molekylärbiologi; Molecular Biology;

    Abstract : Background: In all higher organisms, the nuclear DNA is condensed into nucleosomes that consist of DNA wrapped around a core of highly conserved histone proteins. DNA bound to histones and other structural proteins form the chromatin. READ MORE

  6. 4. bHLH transcription factors in differentiating neuroblastoma cells

    Author : Anna Grynfeld; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bHLH; Neuroblastoma; HES-1; HASH-1; N-Myc; differentiation; Mad; Medicine human and vertebrates ; Medicin människa och djur ;

    Abstract : Neuroblastoma is a tumor of the sympathetic nervous system, and arises during early childhood. The tumor is highly heterogeneous and evidence, such as expression of genes normally only expressed during embryonic and fetal stages, suggests that the tumor is of embryonic origin and that the tumor arises as a consequence of perturbed differentiation during the development of the sympathetic nervous system. READ MORE

  7. 5. Electrochemical reduction of protons and organic molecules in hydrogen technologies : Liquid Organic Hydrogen carrier and Hydrogen Evolution

    Author : Hamid Ghorbani Shiraz; Magnus Berggren; Xavier Crispin; Ola Wendt; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hydrogen Storage; LOHC; Hydrogen Evolution; Electrocatalyst;

    Abstract : In accordance with preventable actions to mitigate the effect of climate change in the modern societal applications, renewable energy is an unavoidable and decisive factor in the energy industry. The energy sources that offer non-depleted and environment-friendly pathways for the energy sector are in focus. READ MORE