Search for dissertations about: "robert daniels"

Found 4 swedish dissertations containing the words robert daniels.

2. 1. Influenza neuraminidase assembly : Evolution of domain cooperativity

   Author : Diogo da Silveira Vieira da Silva; Robert Daniels; Ron Fouchier; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Influenza; neuraminidase; assembly; transmembrane domain; evolution; Biochemistry; biokemi;

   Abstract : Influenza A virus (IAV) is one of the most common viruses circulating in the human population and is responsible for seasonal epidemics that affect millions of individuals worldwide. The need to develop new drugs and vaccines against IAVs led scientists to study the main IAV surface antigens hemagglutinin (HA) and neuraminidase (NA). READ MORE

4. 2. Influenza A Virus : Spatial analysis of influenza genome trafficking and the evolution of the neuraminidase protein

   Author : Dan Dou; Robert Daniels; Martin Schwemmle; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Influenza A virus; IAV; neuraminidase; NA; IAV genome trafficking; viral entry; viral replication; co-infection; antigenic drift; antigenic shift; NA assembly; transmembrane domain; evolution; Biochemistry; biokemi;

   Abstract : Influenza A viruses (IAVs) are a common infectious agent that seasonally circulates within the human population that causes mild to severe acute respiratory infections. The severity of the infection is often related to how the virus has evolved with respect to the pre-existing immunity in the population. READ MORE

5. 3. NA transmembrane domain : Amphiphilic drift to accommodate two functions

   Author : Johan Nordholm; Robert Daniels; Ervin Fodor; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; influenza; IAV; neuraminidase; NA; transmembrane domain; TMD; secretory protein; ER-targeting sequence; ER-targeting sequence coding region; protein regulation; NS1; GALLEX; Biochemistry; biokemi;

   Abstract : Neuraminidase (NA) is one of two major antigens on the surface of influenza A viruses. It is comprised of a single N-terminal transmembrane domain (TMD), a stalk domain, and a C-terminal enzymatic head domain that cleaves sialic acid, most notably to release new particles from the host cell surface. READ MORE

6. 4. Influenza Neuraminidase : Novel mechanisms of influenza NA that enable adaptation and promote diversification

   Author : Hao Wang; Robert Daniels; Colin Russell; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Influenza; IAV; neuraminidase; transmembrane domain; the central Ca2 binding site; heterotetrameric formation; viral incorporation; evolution; adaptation; diversification; Biochemistry; biokemi;

   Abstract : Influenza A viruses (IAVs) are one of the most common human respiratory pathogens and are largely responsible for the seasonal influenza epidemics that cause mild to severe disease. The two IAV glycoproteins, hemagglutinin (HA or H) and neuraminidase (NA or N), serve as the major surface antigens and also are the main determinants of infectivity, pathogenicity and transmissibility. READ MORE