Search for dissertations about: "rodent and human neural stem cells"

Showing result 1 - 5 of 6 swedish dissertations containing the words rodent and human neural stem cells.

  2. 1. Isolation and characterization of adult neural stem cells

    Author : Clas B Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Intermediate filaments; GFAP; nestin; scar formation; regeneration; rodent and human neural stem cells; multipotency.;

    Abstract : Injury to the central nervous system (CNS) is one of man's most handicapping situations resulting in severe functional impairment and in some cases a vegetative state where life is supported artificially. The brain and spinal cord, constituting the CNS, have been viewed for decades as having limited capacity of regeneration with no neurogenesis in the adult. READ MORE

  4. 2. Epigenetic and bioelectronic tools to study neural stem cells in health and disease

    Author : Christina Neofytou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Brain development is a highly controlled, complex, and dynamic process. The mechanisms of its control need to accommodate the constantly changing contexts which, overtime, support the emergence of new neural structures and functions. READ MORE

  5. 3. Neural stem cell engraftment : functional interactions, brain repair and gap junctions

    Author : Johan Jäderstad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neural stem cell (NSC) engraftment therapies show increasing promise as potential cures for several of the diseases of the central nervous system. Traditionally, functional improvements after NSC engraftment have been attributed to replacement of lost neurons and astrocytes, remyelination and support of adjacent cells at risk. READ MORE

  6. 4. From stem cells to neurons : a BMPy ride

    Author : Therese Andersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Pinpointing the mechanisms behind the formation of the vertebrate development has been an intriguing and challenging task for researchers for several decades. In the 1980s two independent groups managed to isolate cells from the inner cell mass of a mouse blastocyst and to culture and expand them in vitro, while maintaining their pluripotency. READ MORE

  7. 5. Neuronal dysfunction, death and repair in the MPTP model of Parkinson's disease

    Author : Kioumars Delfani; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Parkinson s Disease; apoptosis; substantia nigra; dopamine; MPTP; neurogenesis; intracranial transplantation; ATP; PET; stereology; diethyldithiocarbamate; 7-nitroindazole; mouse; squirrel monkey; non- human primate;

    Abstract : We have used mouse and non-human primate models of Parkinson's Disease to analyze neuronal dysfunction, death and repair in the mammalian brain, utilizing the neurotoxin 1-methyl-4-phenyl1,2,3,6-tetrahydropyridine (MPTP). In a series of experiments we assessed the effects of diethyIdithiocarbamate (DDC) on MPTP toxicity, analyzing striatal and midbrain dopamine levels as well as neuronal loss. READ MORE