Search for dissertations about: "role for animals"

Showing result 11 - 15 of 501 swedish dissertations containing the words role for animals.

  2. 11. On the role of forebrain cholinergic innervation for phencyclidine-induced behaviors and gene expression patterns

    Author : Sophia Savage; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The basalo-cortical cholinergic innervation reaches neural targets in cortex cerebri where it modulates the incoming sensory information, regulating arousal, attention, vigilance, memory and cognition. Progressive de generation of the cholinergic neurons in the basal forebrain is considered a hallmark of Alzheimer ’s disease related to cognitive impairment in this condition. READ MORE

  4. 12. Role of Endogenous BDNF and NT3 for Synaptic Transmission and Plasticity in the Dentate gyrus

    Author : Klara Olofsdotter; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hippocampus; dentate gyrus; GABA; glutamate; synaptic transmission; synaptic plasticity; Brain-derived neurotrophic factor; neurotrophin 3; Neurologi; neurophysiology; neuropsychology; Neurology; electrophysiology; neurofysiologi; neuropsykologi;

    Abstract : The neurotrophins, notably brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), modulate synaptic transmission and synaptic plasticity in the adult mammalian brain. Recent data suggest that neurotrophins might be mediators of activity-dependent synaptic plasticity. READ MORE

  5. 13. The role of galanin in chronic pain mechanisms

    Author : Karin Hygge Blakeman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Galanin; galanin receptor 1; pain; neuropathic pain; transgenic mice; knock-out mice; microdialysis;

    Abstract : The general aim of these studies is to further elucidate the role of galanin in pain mechanisms. We have utilized normal and genetically modified animals and a variety of techniques. READ MORE

  6. 14. Role of angiogenesis in cancer invasion and metastasis

    Author : Pegah Rouhi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer metastasis is a complex process that involves an elaborate interplay between malignant cells and various host cellular and molecular components. The metastatic cascade consists of several discrete but non-separable steps, including: 1) malignant transformation of cells; 2) intravasation and dissemination of tumor cells into the circulation or lymphatic system; 3) transport of malignant cells to distal organs and tissues; 4) adherence of tumor cells to distal sites; 5) formation of the initial metastatic niches, and 6) angiogenesis-dependent re-growth of metastatic foci to clinically detectable tumors. READ MORE

  7. 15. Identification and characterisation of chitin and cellulose synthases in oomycetes : New tools for biochemical studies and structure determination

    Author : Stefan Klinter; Vincent Bulone; Lauren S. McKee; Mirjam Czjzek; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; biochemical characterisation; cellulose synthase; chitin synthase; in vitro activity assay; microtubule-interacting and trafficking domain; nanoparticle; oomycetes; phylogenetic analysis; yeast engineering; biokemisk karakterisering; cellulosasyntas; kitinsyntas; in vitro aktivitetsanalys; mikrotubulus-interagerande och -trafikerande domän; nanopartikel; oomyceter; fylogenetisk analys; jäst proteinteknik; Bioteknologi; Biotechnology;

    Abstract : Despite resembling ‘true’ fungi in terms of morphological features, oo­mycetes form a distinct eukaryotic lineage of filamentous microorganisms that belongs to the stramenopiles, a group of protists also comprising the closely-related brown algae and diatoms. Many oomycetes are devastating pathogens of plants and animals, globally causing significant economic los­ses in the agriculture and aquaculture industries, and posing considerable environmental damage to natural ecosystems. READ MORE