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Showing result 1 - 5 of 24 swedish dissertations matching the above criteria.

  2. 1. Ropivacaine : An experimental and clinical study with special reference to analgesic, circulatory and antiinflammatory effects

    Author : Ingemar Cederholm; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Aims of the study: 1. to compare ropivacaine, a new long-acting amino-amide local anaesthetic drug, and bupivacaine (with/without adrenaline) concerning dermal analgesia and local vascular effects, 2. to design a suitable test procedure to evaluate changes in skin blood flow after intradermal injection of local anaesthetics, 3. READ MORE

  4. 2. Drug Transport and Metabolism in Rat and Human Intestine

    Author : Sofia Berggren; Hans Lennernäs; Janet Hoogstraate; Patrick Augustijns; Uppsala universitet; []
    Keywords : Biopharmacy; Ussing chamber; microsome; single-pass perfusion; human; rat; intestine; permeability; efflux; P-glycoprotein; metabolism; cytochrome P450; ropivacaine; lidocaine; bupivacaine; Biofarmaci; PPX;

    Abstract : One of the aims of this thesis was to investigate the involvement of efflux proteins, such as the P-glycoprotein (Pgp), in the drug transport in different regions of the rat and the human intestine. The intestinal extrusion of intracellularly formed CYP3A4 metabolites, including whether this extrusion might be mediated by Pgp, was also studied. READ MORE

  5. 3. Local infiltration analgesia in knee arthroplasty

    Author : Per Essving; Kjell Axelsson; Lars Weidenhielm; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Knee arthroplasty; minimally invasive surgery; ropivacaine; ketorolac; intrathecal morphine; local infiltration analgesia; Surgery; Kirurgi;

    Abstract : Local infiltration analgesia (LIA) is a new technique for postoperative pain management following knee arthroplasty. LIA involves a long-acting local anesthetic (ropivacaine), a non-steroid anti-inflammatory drug (ketorolac) and epinephrine infiltrated into the knee joint during surgery and injected postoperatively via a catheter. READ MORE

  6. 4. On Factors Influencing the Clinical Outcome in Orthognathic Surgery

    Author : Fredrik Widar; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Orthognathic surgery; Intermaxillary fixation; Iatrogenic root damage; Osteotomy; Sagittal split ramus; Steroid; Hypoesthesia; Inferior alveolar nerve; Risk factors; Smoking; Anaesthesia; Haemodynamic; Remifentanil; Ropivacaine; Recovery;

    Abstract : ABSTRACT Background. Orthognathic surgery means surgical correction of dentofacial and congenital deformities, which includes unsatisfactory facial aesthetics, malpositioned teeth, jaw moutcome osurgery. Developments within the invasive surgery and pharmacological modification of inflammatory responses. READ MORE

  7. 5. Exploratory clinical development of ropivacaine, a local anaesthetic, in ulcerative colitis

    Author : Eva Arlander; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Drug development; ulcerative colitis; ropivacaine; rectal administration; pharmacokinetics; metabolism.;

    Abstract : The aims of this thesis were to explore the clinical pharmacology of ropivacaine gel as a potential new rectal therapy for ulcerative colitis (UC). The studies included pharmacokinetics, tolerability, preliminary efficacy in patients, formulation factors and drug-drug interactions. READ MORE