Search for dissertations about: "round cell tumor"

Showing result 1 - 5 of 8 swedish dissertations containing the words round cell tumor.

2. 1. Liposarcomas - proliferation, senescence and the role of DDIT3

   Author : Christina Kåbjörn-Gustafsson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Liposarcoma; FUS-DDIT3; TP53; senescence;

   Abstract : Lipomatous tumors comprise benign and malignant forms called lipomas and liposarcomas. Myxoid/round cell liposarcoma (MLS/RCLS) is the second most common liposarcoma and is characterized by the fusion oncogenes FUS-DDIT3 or EWSR1-DDIT3. READ MORE

4. 2. Functional characterization of the liopsarcoma-associated fusion oncigene FUS-DDIT3

   Author : Melker Göransson; Göteborgs universitet; []
   Keywords : Myxoid round cell liposarcoma; fusion oncogenes; FUS; DDIT3; tumor development; cell cycle regulators; IL6; IL8; NFkappaB.;

   Abstract : Fusion genes represent a growing class of translocation-derived potent oncogenes that frequently show tumor type-specific expression. We have studied the myxoid/round cell liposarcoma (MLS/RCLS)-specific FUS-DDIT3 fusion, with the aim of functionally characterizing this fusion oncogene in sarcoma development. READ MORE

5. 3. Molecular studies of genetic changes in myxoid and round cell liposarcoma

   Author : Sofia Järnum; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; Cytologi; onkologi; cancer; Medicine human and vertebrates ; Medicin människa och djur ; oncology; Cytology; autocrine loop; RDA; persephin; RET; LEPREL1; translocation; fusion gene; liposarcoma; TLS; CHOP;

   Abstract : Chromosomal translocations commonly result in the production of fusion genes and the fusion genes are often tumor-type specific. In myxoid and round cell liposarcomas (MLS/RCLS), almost 95% of the cases carry a t(12;16)(q13;p11). In the remaining 5% of the MLS/RCLS tumors, another translocation and fusion gene can be found, i.e. READ MORE

6. 4. Electron Microscopy in Diagnostic Pathology with Reference to Mesenchymal Tumors

   Author : Birgitta Carlén; Tumörmikromiljö; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; synovial sarcoma; Kaposi´s sarcoma; epithelioid sarcoma; parachordoma; alveolar soft part sarcoma; small cell malignant tumors of childhood and adolescence; cultured cells; surgical specimens; Transmission electron microscopy; fine needle aspiration; General pathology; pathological anatomy; Patologi allmän ; patologisk anatomi;

   Abstract : The experience acquired over a period of 15 years of diagnostic electron microscopy of fine needle aspirates and surgical specimens constitutes the base for this thesis. Some of the tumors analyzed represent rare soft tissue tumors, and consequently not very often ultrastructurally described. READ MORE

7. 5. FET proteins in cancer and development

   Author : Mattias K Andersson; Göteborgs universitet; []
   Keywords : FUS; EWS; TAF15; FUS-DDIT3; myxoid liposarcoma; NF-κB; NFKBIZ; FLT1; CDK2;

   Abstract : Chromosomal translocations leading to rearrangements of FET family genes (FUS, EWSR1 and TAF15) are found in numerous human cancers. These genetic alterations result in the formation of fusion oncogenes that express potent chimeric oncoproteins able to promote tumor development. READ MORE