Search for dissertations about: "runx2"

Showing result 1 - 5 of 11 swedish dissertations containing the word runx2.

  2. 1. The roles of osteoclasts and RUNX2 in the progression of prostate cancer bone metastases

    Author : Junchi Huang; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Castration-resistant prostate cancer; Bone metastases; RUNX2; Osteoclasts;

    Abstract : Metastasis to the skeleton is the major cause of death from prostate cancer (PC). Patients with metastatic PC are treated with androgen deprivation therapy (ADT) to decrease testosterone levels and thereby inhibit further growth of the tumor. READ MORE

  4. 2. RUNX1/AML1 functions and mechanisms regulating granulocyte-macrophage colony-stimulating factor transcription

    Author : Hebin Liu; Sven Påhlman; Umeå universitet; []
    Keywords : RUNX1 AML1; Granulocyte-macrophage colony-stimulating factor GM-CSF ; Calcineurin; CaMKII; Ets1; Transforming growth factor-b TGF-b ; Smad3; molekylärbiologi; Molecular Biology;

    Abstract : Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent cytokine involved in the production and function of hematopoietic cells, and GM-CSF plays in particular a major role in responses to infection and physiological and pathological inflammatory processes. GM-CSF is produced in many cell types, and increases in the intracellular Ca2+ concentration are, like in many other systems, of major importance in the intracellular signaling that determines GM-CSF expression after receptor stimulation of the cells. READ MORE

  5. 3. The regulatory role of osteoblasts in castration-resistant growth of prostate cancer

    Author : Malin Hagberg Thulin; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; castration-resistant prostate cancer; bone metastases; osteoblasts;

    Abstract : Bone metastasis of a predominantly osteoblastic (sclerotic) nature is the outcome for the vast majority of patients with castration-resistant prostate cancer (CRPC). Pathologically, osteoblastic tumors are characterized by excessive bone formation resulting in decreased quality of life due to severe pain, fractures, nerve compression, and a suppressed immune system. READ MORE

  6. 4. The role of computer-aided design and surface chemistry on Cell-scaffold interactions

    Author : Sun Yang; Anna Finne-Wistrand; Ann-Christine Albertsson; Jinshan Pan; My Hedhammar; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amorphous degradable copolymer; aliphatic polyester; 3D fiber deposition; computer-aided design; Tween 80; BMSC; hOB; porous scaffolds;

    Abstract : Cell interactions and cell response to three dimensional scaffolds based on poly(L-lactide-co-1,5-dioxepan-2-one) [poly(LLA-co-DXO)] and poly(L-lactide-co-e-caprolactone) [poly(LLA-co-CL)] wereimprovedstudiedby increasing surface hydrophilicity and by using computer-aided scaffold design. Different amounts of Tween 80 (3, 10, 20 wt%) were mixed with the copolymer and it was found that the water contact angle decreased significantly with the amount of Tween 80. READ MORE

  7. 5. Mesenchymal stem cell regeneration and differentiation after anti inflammatory drug exposure

    Author : Maritha Kumlin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Traumatic and degenerative pathologies of the musculoskeletal system are common and often involve injuries of multiple mesenchymal tissues including bone, cartilage, tendons and ligaments. Medical intervention is frequently initiated to relieve pain, restore biomechanical function, with aim to return to the desired level of activity as soon as possible. READ MORE