Search for dissertations about: "s-phase checkpoint"

Showing result 1 - 5 of 18 swedish dissertations containing the words s-phase checkpoint.

  2. 1. Cell cycle regulation in cancer: A noncoding perspective

    Author : Mohamad Ali; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Long Noncoding RNA; lncRNA; Cell cycle; S phase; Mitosis; Checkpoint; Cancer; SCAT7; LY6K-AS;

    Abstract : The cell cycle progression is tightly regulated to ensure error-free cell replication. The complexity of the transcriptional machinery aids to function in a spatiotemporal pattern across different phases and genomic loci. READ MORE

  4. 2. dNTPs : the alphabet of life

    Author : Dinesh Kumar; Andrei Chabes; Britt-Marie Sjöberg; Umeå universitet; []
    Keywords : ribonucleotide reductase; dNTP pools; s-phase checkpoint; mutagenesis; medicinsk biokemi; Medical Biochemistry;

    Abstract : From microscopic bacteria to the giant whale, every single living organism on Earth uses the same language of life: DNA. Deoxyribonucleoside triphosphates––dNTPs (dATP, dTTP, dGTP, and dCTP)––are the building blocks of DNA and are therefore the “alphabet of life”. READ MORE

  5. 3. DNA precursor asymmetries, Mismatch Repair and their effect on mutation specificity

    Author : Robert Buckland; Andrei Chabes; Juan Méndez; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA Replication Fidelity; Mutations; dNTP pools; Mismatch Repair; Checkpoint; Ribonucleotide Reductase; Msh2; medicinsk biokemi; Medical Biochemistry; molekylärbiologi; Molecular Biology;

    Abstract : In order to build any structure, a good supply of materials, accurate workers and quality control are needed. This is even the case when constructing DNA, the so-called “Code of Life.” For a species to continue to exist, this DNA code must be copied with incredibly high accuracy when each and every cell replicates. READ MORE

  6. 4. The Heterogenic Final Cell Cycle of Retinal Horizontal Cells

    Author : Shahrzad Shirazi Fard; Finn Hallböök; Ulla Pirvola; Uppsala universitet; []
    Keywords : Apoptosis; Checkpoint; DNA damage; Differentiation; Heteroploid; Endoreplication; Proliferation; Tumor; Neuroscience; Neurovetenskap;

    Abstract : The cell cycle is a highly complex process that is under the control of several pathways.  Failure to regulate and/or complete the cell cycle often leads to cell cycle arrest, which may be followed by programmed cell death (apoptosis). One cell type that has a variety of unique cell cycle properties is the horizontal cell of the chicken retina. READ MORE

  7. 5. The role of RNA-binding motif 3 in epithelial ovarian cancer: A biomarker discovery approach

    Author : Åsa Ehlén; Malmö Patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA integrity checkpoint; cisplatin treatment; prognostic predictive marker; RBM3; epithelial ovarian cancer; Chk1; Chk2; MCM3;

    Abstract : Epithelial ovarian cancer (EOC) is the most lethal of all gynaecological malignancies and there is an urgent need to develop new prognostic and treatment predictive biomarkers for a more efficient therapy. The discovery of the RNA-binding motif protein 3 (RBM3) as a putative cancer biomarker was based on its differential expression in various cancer forms in the Human Protein Atlas (HPA). READ MORE