Search for dissertations about: "safety and efficacy"

Showing result 1 - 5 of 236 swedish dissertations containing the words safety and efficacy.

  2. 1. Antimicrobial peptides in the treatment of infectious and inflammatory conditions : Preclinical studies of mechanism of action, efficacy, and safety

    Author : Camilla Björn; RISE; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antimicrobial peptides; AMPs; innate immunity; infection; inflammation; mechanism of action; efficacy; safety; antimicrobial resistance; antibiotic resistance; Antimicrobial peptides; AMPs; innate immunity; infection; inflammation; mechanism of action; efficacy; safety; antimicrobial resistance; antibiotic resistance;

    Abstract : The rapid emergence of antibiotic-resistant microbes worldwide and the urgent need of new antimicrobial agents have stimulated interest in antimicrobial peptides (AMPs) as new therapeutics for treatment of infectious diseases. AMPs are present in all living species and constitute an important part of the innate immune system in multicellular organisms, including humans. READ MORE

  4. 2. Laser treatment in glaucoma : efficacy and safety

    Author : Erika Rasmuson; Gauti Jóhannesson; Christina Linden; Björn Lundberg; Mika Harju; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glaucoma; laser treatment; intraocular pressure; glaucoma treatment; glaukom; laserbehandling; ögontryck; glaukombehandling; oftalmiatrik; ophthalmology; oftalmiatrik; ophthalmology;

    Abstract : Glaucoma is a progressive optic neuropathy and the major cause of irreversible blindness worldwide. Although the pathogenesis of glaucoma is not completely understood, the most important risk factor for development and progression of the disease is an elevated intraocular pressure (IOP). READ MORE

  5. 3. Clinical impact of epoetins in the treatment of anemia with special emphasis on patients with lymphoid malignancies. : dosing, iron supplementation and safety

    Author : Michael Hedenus; Jack Lindh; Anders Österborg; Robert Hast; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; anemia; cancer; lymphoproliferative malignancies; erythropoietin; intravenous iron; safety; Oncology; Onkologi; Oncology; onkologi;

    Abstract : The aim of this thesis was to determine the relevant dose of arbepoetin-alfa (DA) in patients with lymphoproliferative diseases (LPD) and chemotherapy induced anemia (CIA), to study the clinical impact of intravenous (IV) iron supplementation combined with epoetin beta treatment, to identify factors that might predict hemoglobin (Hb) response to treatment with epoetins and to investigate safety of DA.A dose-finding phase II study was able to assess a reasonable DA dose of 2. READ MORE

  6. 4. Cognitive therapy and behavioral therapy for insomnia disorder : efficacy, moderators and mediators

    Author : Rikard Sunnhed; Markus Jansson-Fröjmark; Per Carlbring; Hugo Hesser; Ståle Pallesen; Stockholms universitet; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Behavior Therapy; Cognitive Therapy; Insomnia; internet-delivered; efficacy; mediators; moderators; personalized medicine; Psychology; psykologi;

    Abstract : Insomnia disorder is the second most prevalent mental disorder and the most prevalent sleep disorder. Cognitive Behavioral Therapy for Insomnia (CBT-I) is considered the treatment of choice with well-documented effects. READ MORE

  7. 5. Improving management of STEMI patients treated with primary PCI : Pharmacotherapy, renal function estimation and gender perspective

    Author : Dimitrios Venetsanos; Eva Swahn; Joakim Alfredsson; Sofia Sederholm-Lawesson; Sigrun Halvorsen; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : This thesis focused on the acute management of patients with ST-segment elevation myocardial infarction (STEMI) in an effort to provide information that may improve outcome. The aim was to evaluate the efficacy and safety of bivalirudin versus unfractionated heparin (UFH) in STEMI patients during primary PCI. READ MORE