Search for dissertations about: "sample of Swedish twin"

Showing result 1 - 5 of 25 swedish dissertations containing the words sample of Swedish twin.

  2. 1. Genetic studies of depressive symptoms

    Author : Mårten Jansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Depressive Symptoms; Twin; Heritability; Serotonin receptor 2A; Serotonin transporter; MAOA; MAOB; Thrombocyte MAO activity; Linkage Disequilibrium.;

    Abstract : This thesis is focused on depressive symptoms particularly in late fife. Depressive symptoms are associated with serious negative outcomes a greater level of disability and with excess morbidity and mortality. READ MORE

  4. 2. DNA methylation and aging : a longitudinal study of old Swedish twins

    Author : Yunzhang Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : DNA methylation is a well-known biomarker of aging. Many previous studies have reported the change of DNA methylation patterns with age, and analyzed DNA methylation in association with aging outcomes. However, most publications were based on cross-sectional data while longitudinal evidence was largely missing. READ MORE

  5. 3. Genetics and biomarkers of frailty : towards individualized management of the frailty syndrome

    Author : Ka Long Jonathan Mak; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Frailty is an age-related, dynamic state of multisystem physiological decline and is a strong predictor of disability and mortality. To move towards an individualized management of frailty, a better understanding of its biological underpinnings and an early identification of frail older adults are necessary. READ MORE

  6. 4. Personality, stress and risk of Parkinson's disease

    Author : Johanna Sieurin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The objective of this thesis was to investigate the relationship of personality and stress with subsequent risk of Parkinson’s disease (PD). In Study I, we conducted a population-based cohort study using questionnaire data from the Swedish Twin Registry to explore whether the personality traits, neuroticism and introversion, were associated with later PD risk. READ MORE

  7. 5. Comparative sequencing of candidate genes in complex disease

    Author : Shane McCarthy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA; Sequencing; Complex Disease; Candidate Gene;

    Abstract : Complex multi-factorial diseases such as cardiovascular, metabolic, neurological and respiratory disorders affect a great number of people across the world. In the post-Human Genome Sequencing era, genome wide association studies are increasingly viable alternatives to linkage approaches in locating disease genes. READ MORE