Search for dissertations about: "scFv"

Showing result 1 - 5 of 33 swedish dissertations containing the word scFv.

  1. 1. Tailoring of Antibody Arrays - Technical Advances Towards Global Proteome Analysis

    Author : Linn Petersson; Institutionen för Immunteknologi; []
    Keywords : antibody arrays; recombinant antibodies; scFv; miniaturization of arrays; immobilization of scFv; global proteome analysis; biomarker discovery;

    Abstract : Abstract The number of cancer and autoimmune disease diagnoses increases in our society, which place high demands on the health care system. Being able to tailor treatments for each individual patient is called "Personalized medicine", and could revolutionize the care in the future. READ MORE

  2. 2. Technological Advancements in Affinity Proteomics : From planar antibody microarrays towards a solution-based platform

    Author : Mattias Brofelth; Institutionen för Immunteknologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Affinity proteomics; Antibody microarrays; scFv; Biomarkers; MIAS;

    Abstract : Abstract: Proteomics has the potential to deliver disease-associated biomarkers that could provide diagnostic, prognostic and predictive information to enable precision medicine. Affinity proteomics, most commonly based on antibodies and their ability to specifically capture target proteins, has emerged has a valuable tool in biomarker discovery. READ MORE

  3. 3. Biosensing and Protein Array Design using Lipid Assemblies

    Author : Charlotte Larsson; Chalmers University of Technology; []
    Keywords : protein adsorption; protein arrays; lipid bilayer; SPR; scFv; lipid vesicle; DNA arrays; QCM-D;

    Abstract : Biomolecular sensing often includes immobilization of biomolecules, e.g. DNA, antibodies etc., to solid supports, where they act as selective recognition elements. READ MORE

  4. 4. Design of recombinant antibody microarrays for global proteome analysis

    Author : Johan Ingvarsson; Institutionen för Immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bioteknik; oncoproteomics; Recombinant antibody microarray; scFv; Biotechnology; plasma proteome analysis;

    Abstract : Antibody-based microarrays are among the new, rapidly emerging technologies within the field of proteomics that has the potential to evolve into a key proteomic research tool, providing novel means to perform early diagnostics, identify biomarkers and gain insights into disease biology. The aim of this thesis, based on five original papers, was to develop antibody microarrays based on human recombinant scFv antibody fragments for large-scale comprehensive proteome analysis. READ MORE

  5. 5. Design of antibody microarrays for global profiling of membrane proteins and soluble proteins

    Author : Linda Dexlin Mellby; Institutionen för Immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; scFv; membrane proteins; proteomics; protein chip; recombinant antibodies; Antibody microarray; protein profiling; membrane proteomics;

    Abstract : Antibody-based microarrays have emerged as an established proteomic technology allowing multiplexed and sensitive profiling of complex proteomes, in a high-throughput and miniaturized manner. Recently, numerous applicative efforts have been pursued generating disease-associated protein signatures that now could be further explored for improved disease diagnostics, prognostics and classification. READ MORE