Search for dissertations about: "scRNA-seq"

Showing result 1 - 5 of 23 swedish dissertations containing the word scRNA-seq.

  2. 1. Exploring Biological Systems using Spatial Transcriptomic Technologies

    Author : Kim Thrane; Joakim Lundeberg; Patrik Ståhl; Ulf Gyllensten; KTH; []
    Keywords : Spatial Transcriptomics; single-cell RNA-seq; scRNA-seq; spatial VDJ; Spatial Isoform Transcriptomics; Biotechnology; Bioteknologi;

    Abstract : The transcriptome and the cells’ spatial organization are important determinants for the functions of biological systems, such as a tumor, brain, or skin tissue. Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for profiling the transcriptome of individual cells. READ MORE

  4. 2. Deciphering neural networks in the somatosensory system using single-cell transcriptomics and rabies tracing

    Author : Jon E. T. Jakobsson; Malin C. Lagerström; Victoria Abraira; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neural networks; somatosensory system; itch; rabies tracing; scRNA-seq;

    Abstract : Itch has evolved to protect us from malicious parasites keen to suck our blood or lay their eggs in our skin. We can detect both the movement of these parasites and the toxins they introduce with specialized neurons called pruriceptors. When we feel an itch, we get a desire to scratch it. READ MORE

  5. 3. Computational methods for analysis and visualization of spatially resolved transcriptomes

    Author : Jose Fernandez Navarro; Joakim Lundeberg; Martin Hemberg; KTH; []
    Keywords : RNA; RNA-seq; single cell; scRNA-seq; transcriptomics; spatial transcriptomics; brain; 3D; Alzheimer’s disease; Bioteknologi; Biotechnology;

    Abstract : Characterizing the expression level of genes (transcriptome) in cells and tis- sues is essential for understanding the biological processes of multicellular or- ganisms. RNA sequencing (RNA-seq) has gained traction in the last decade as a powerful tool that provides an accurate quantitative representation of the transcriptome in tissues. READ MORE

  6. 4. Early fate decisions in hematopoietic stem and progenitor cells. Through the lens of genomic and functional assays

    Author : Fatemeh Safi; Avdelningen för molekylär hematologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; HSCs; singel cell sc ; scRNA-seq; scATAC-seq; CD9; Aging;

    Abstract : Hematopoietic stem cells (HSCs) are rare cells on top of the differentiation hierarchy of hematopoiesis. HSCs are unique in their combined capacity to differentiate into all mature blood lineages and self-renew to maintain the HSC pool. READ MORE

  7. 5. Mapping and annotating the mammalian body-wide protein-coding gene expression

    Author : Max Karlsson; Mathias Uhlén; Linn Fagerberg; Julio Saez-Rodriguez; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein; protein-coding; genes; annotation; atlas; scRNA-Seq; RNA-Seq; transcriptomics; proteomics; Biotechnology; Bioteknologi;

    Abstract : A central aim of fundamental research is to create conditions necessary for fueling further research and innovation. Our understanding of basic biology is central for future developments of tools for diagnosing, monitoring, and treating disease. READ MORE