Search for dissertations about: "scaffold design"

Showing result 1 - 5 of 83 swedish dissertations containing the words scaffold design.

  1. 1. Synthesis of Biomedical Polymers and Scaffold Design

    University dissertation from Stockholm : KTH

    Author : Therese Tyson; Ann-Christine Albertsson; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ring-opening polymerization; tin alkoxide initiator; stannous octoate; poly p-dioxanone ; copolymer; L-lactide; trimethylene carbonate; degradable porous scaffold; NATURAL SCIENCES Chemistry Organic chemistry Polymer chemistry; NATURVETENSKAP Kemi Organisk kemi Polymerkemi;

    Abstract : This work has focused on the development of new improved synthesis methods of biodegradable aliphatic polymers and on the preparation of porous scaffolds for tissue engineering applications. The aim of the first part of the work was the synthesis of poly(p-dioxanone) (PPDX) homopolymers with high molecular weights using the cyclic tin alkoxide initiator 1-di-n-butyl-1-stanna-2,5-dioxacyclopentane. READ MORE

  2. 2. Hyaluronan Based Biomaterials with Imaging Capacity for Tissue Engineering

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Yu Zhang; Dmitri Ossipov; Carsten Werner; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; hyaluronan; hydrogel; scaffold; tissue engineering; imaging; interpenetrating network; MRI; fluorescence imaging; scaffold degradation;

    Abstract : This thesis presents the preparation of hyaluronan-based biomaterials with imaging capability and their application as scaffolds in tissue engineering. First, we have synthesized HA derivatives functionalized with different chemoselective groups. READ MORE

  3. 3. Modulating Sirtuin Activity - Design, Synthesis and Evaluation of Sirtuin 2 Inhibitors

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Tina Seifert; Göteborgs universitet.; Gothenburg University.; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Sirtuin; SIRT2; Inhibitors; Chroman-4-ones; Chromones; Benzothiadiazine-1; 1-dioxides; Saccharin; Scaffold; Structure-activity relationship; Antiproliferative properties; Binding site; Homology modeling; Photoaffinity labeling; Diazirine; Mass spectrometry;

    Abstract : Sirtuins (SIRTs) are NAD+-dependent lysine deacetylating enzymes targeting histones and a multitude of non-histone proteins. The SIRTs have been related to important cellular processes such as gene expression, cell proliferation, apoptosis and metabolism. They are proposed to be involved in the pathogenesis of e.g. READ MORE

  4. 4. degradable electroactive polymers: Synthesis, Macromolecular architecture and scaffold design

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Baolin Guo; Ann-Christine Albertsson; Patric Jannasch; [2011]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Poly lactide ; poly ε-caprolactone ; ring-opening polymerization; carboxyl-capped aniline trimer; carboxyl-capped aniline pentamer; phenyl amino-capped aniline tetramer; coupling reaction; DCC DMAP system; degradability; electroactivity; conductivity; macromolecular architecture; chitosan; hydrogel; block copolymer; functionalization; oxidative coupling reaction; self-assembly; toxicity; tubular porous scaffold; neural tissue engineering.;

    Abstract : Electrically conducting polymers induce specific cellular responses at the molecular level. One of the crucial limitations of the use of conducting polymers in tissue engineering is their inability to degrade. READ MORE

  5. 5. Statistical molecular design, QSAR modeling, and scaffold hopping – Development of type III secretion inhibitors in Gram negative bacteria

    University dissertation from Umeå : VMC-KBC

    Author : Markus Dahlgren; Mikael Elofsson; Bo Nordén; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Statistical molecular design; QSAR; synthesis; type III secretion; virulence; scaffold hopping; NATURAL SCIENCES Chemistry Organic chemistry Bioorganic chemistry; NATURVETENSKAP Kemi Organisk kemi Bioorganisk kemi; datorlingvistik; computational linguistics;

    Abstract : Type III secretion is a virulence system utilized by several clinically important Gram-negative pathogens. Computational methods have been used to develop two classes of type III secretion inhibitors, the salicylidene acylhydrazides and the acetylated salicylanilides. READ MORE