Search for dissertations about: "scaffold diversity"

Showing result 1 - 5 of 12 swedish dissertations containing the words scaffold diversity.

  2. 1. Exploring evolutionary and chemical space using chemoinformatic tools and traditional methods in pharmacognosy

    Author : Astrid Henz Ryen; Anders Backlund; Thierry Kogej; Fernando B. Da Costa; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; angiosperm chemistry; physicochemical properties of plant specialized metabolites; chemical diversity; chemical space; sesquiterpene lactones; scaffold diversity; molecular framework; cluster analysis; ECFP6; Lindera benzoin; sesquiterpenes; anti-inflammatory; Farmakognosi; Pharmacognosy;

    Abstract : The number of new drugs coming to the market is declining while interest in lead discovery from natural resources is seeing a revival. Although methods for isolation and identification of natural products have advanced tremendously, methods for selection of potential leads have fallen behind. READ MORE

  4. 2. Novel binding specificities engineered into the scaffold of a carbohydrate binding module

    Author : Lavinia Cicortas Gunnarsson; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bioteknik; Biotechnology; carbohydrate binding module; binding specificity; selection; combinatorial library; scaffold; protein engineering;

    Abstract : The growing field of biotechnology is in constant need of proteins that can function as recognition tools for separational, analytical and therapeutic purposes. Different molecular engineering approaches are applied on natural proteins in order to create variants with desired properties. READ MORE

  5. 3. Modulating Sirtuin Activity - Design, Synthesis and Evaluation of Sirtuin 2 Inhibitors

    Author : Tina Seifert; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Sirtuin; SIRT2; Inhibitors; Chroman-4-ones; Chromones; Benzothiadiazine-1; 1-dioxides; Saccharin; Scaffold; Structure-activity relationship; Antiproliferative properties; Binding site; Homology modeling; Photoaffinity labeling; Diazirine; Mass spectrometry;

    Abstract : Sirtuins (SIRTs) are NAD+-dependent lysine deacetylating enzymes targeting histones and a multitude of non-histone proteins. The SIRTs have been related to important cellular processes such as gene expression, cell proliferation, apoptosis and metabolism. They are proposed to be involved in the pathogenesis of e.g. READ MORE

  6. 4. degradable electroactive polymers: Synthesis, Macromolecular architecture and scaffold design

    Author : Baolin Guo; Ann-Christine Albertsson; Patric Jannasch; KTH; []
    Keywords : Poly lactide ; poly ε-caprolactone ; ring-opening polymerization; carboxyl-capped aniline trimer; carboxyl-capped aniline pentamer; phenyl amino-capped aniline tetramer; coupling reaction; DCC DMAP system; degradability; electroactivity; conductivity; macromolecular architecture; chitosan; hydrogel; block copolymer; functionalization; oxidative coupling reaction; self-assembly; toxicity; tubular porous scaffold; neural tissue engineering.;

    Abstract : Electrically conducting polymers induce specific cellular responses at the molecular level. One of the crucial limitations of the use of conducting polymers in tissue engineering is their inability to degrade. READ MORE

  7. 5. Studies of different secondary metabolites : Natural products from the mevalonate pathway

    Author : Mariela Alejandra Gonzales Ramirez; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Natural products; fungi; Galiellalactone; Galiella rufa; Trichilia adolfi; benzofuran;

    Abstract : Natural products, also called secondary metabolites, are small molecules that are not involved in main life processes. These can be produced by any living organism and play important roles as chemical weapons, protecting the organism from the competitive environment. READ MORE