Search for dissertations about: "scaffold"

Showing result 11 - 15 of 299 swedish dissertations containing the word scaffold.

  2. 11. Modulating Sirtuin Activity - Design, Synthesis and Evaluation of Sirtuin 2 Inhibitors

    Author : Tina Seifert; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Sirtuin; SIRT2; Inhibitors; Chroman-4-ones; Chromones; Benzothiadiazine-1; 1-dioxides; Saccharin; Scaffold; Structure-activity relationship; Antiproliferative properties; Binding site; Homology modeling; Photoaffinity labeling; Diazirine; Mass spectrometry;

    Abstract : Sirtuins (SIRTs) are NAD+-dependent lysine deacetylating enzymes targeting histones and a multitude of non-histone proteins. The SIRTs have been related to important cellular processes such as gene expression, cell proliferation, apoptosis and metabolism. They are proposed to be involved in the pathogenesis of e.g. READ MORE

  4. 12. Human embryonic stem cells for bone engineering applications

    Author : Giuseppe Maria de Peppo; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human skeleton; bone; bone defects; bone regeneration; regenerative medicine; tissue engineering; biomaterials; scaffold; biocoral; titanium; osseointegration bioreactor; human stem cells; embryonic stem cells; mesenchymal stem cells; embryonic-derived progenitors; osteogenic differentiation; mineralization; immune response; in vitro; in vivo;

    Abstract : The human skeleton represents the supporting structure of the organism and accounts for about 20 percent of the total body mass. Despite its intrinsic capacity to regenerate and self-repair, this ability is limited and repair therapies are needed in a large number of clinical cases. READ MORE

  5. 13. Development and optimization of a 3D in vitro model for osteogenic biomaterial evaluation

    Author : Luis Oliveros Anerillas; Peyman Kelk; Paul J. Kingham; Mikko Lammi; Jöns Hilborn; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; angiogenesis; biomaterial; bone marrow mesenchymal stem cells; bone regeneration; hydrogel; osteoinduction; osteogenesis; scaffold; type I collagen; 3D culture; biology; biologi; biomedical laboratory science; biomedicinsk laboratorievetenskap; Medical Cell Biology; medicinsk cellbiologi;

    Abstract : Despite the innate regenerative capabilities of bone tissue, self-repair is impaired when an injury exceeds the critical size threshold because of trauma, congenital, or pathological conditions. Autologous transplantation is the gold standard to reconstruct large bone defects. READ MORE

  6. 14. Hyaluronan Derivatives and Injectable Gels for Tissue Engineering

    Author : Kristoffer Bergman; Tim Bowden; Jöns Hilborn; Jeffrey Hubbell; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hyaluronan; Hydrogel; Tissue Engineering; Scaffold; Minimally invasive strategy; Bone morphogenetic protein; Hydroxyapatite; Bone; Cartilage; Tendon; Polymer chemistry; Polymerkemi;

    Abstract : The present work describes the preparation of hyaluronan derivatives and hydrogels with potential use in tissue engineering applications. A potentially injectable hydrogel consisting of hyaluronan and collagen was successfully used to grow neurons in vitro by encapsulation of neural stem and progenitor cells. READ MORE

  7. 15. Closed-loop strategy for valorization of starch : From starch to functionalized starch biomaterials and bioplastics

    Author : Duo Wu; Minna Hakkarainen; Elisabetta Ranucci; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Starch; Nano-graphene oxide; Microwave; Valorization; Scaffold; Biomineralization; Bioplastics; Compatibilizer; Plasticizer; Fiber- och polymervetenskap; Fibre and Polymer Science;

    Abstract : The desire to utilize renewable resources and avoid wastes drives us to develop new concepts for material design. Non-edible starch feedstocks and starch bioplastic wastes were previously considered useless. READ MORE