Search for dissertations about: "scaffold"

Showing result 21 - 25 of 299 swedish dissertations containing the word scaffold.

  2. 21. Engineering alternative scaffold proteins for conditional targeting

    Author : Malin Jönsson; Sophia Hober; Mark Howarth; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein Engineering; Conditional targeting; Calcium; Biotechnology; Bioteknologi;

    Abstract : Engineering naturally occurring proteins enables us to customize affinity domains according to our specific needs, tailoring them to become an important tool in a wide array of applications limited merely by our creativity. One of nature’s ways to regulate protein activity is by creating a functional change through alteration of a protein’s tertiary structure upon interaction with metal ions. READ MORE

  4. 22. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors Incorporating a P2 Cyclopentane-Derived Scaffold

    Author : Marcus Bäck; Anja Sandström; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; HCV; NS3 protease; Proline mimic; Cyclopentane-derived scaffold; Linear inhibitors; Macrocyclic inhibitors; Organic synthesis; Organisk syntes;

    Abstract : This thesis describes the design, synthesis and structure-activity relationships analysis of potential inhibitors targeting the hepatitis C virus (HCV) NS3 protease. Also discussed is the disease caused by HCV infection and the class of enzymes known as proteases. READ MORE

  5. 23. Synthetic Pathways to Aliphatic Polyesters and Scaffold Design

    Author : Therese Tyson; Ann-Christine Albertsson; Elisabetta Ranucci; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Polymer chemistry; Polymerkemi;

    Abstract : As the field of tissue engineering progresses, a continuous development of scaffold fabrication techniques and suitable degradable materials is required to obtain scaffolds with tunable characteristics. This thesis has focused on the development of pathways to synthesize degradable aliphatic polyesters and on the design of highly porous scaffolds from this class of materials. READ MORE

  6. 24. TRÖGER´S BASE AS SCAFFOLD FOR SYNTHETIC RECEPTORS

    Author : Carlos Solano; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; Organisk kemi; Organic chemistry; Makromolekylär kemi; Macromolecular chemistry; Molecular Recognition; Tröger´s base; Synthetic Receptors; Fysikalisk kemi;

    Abstract : This work focuses on the use of the Tröger´s base as organic scaffold for the construction of synthetic receptors for different classes of organic molecules. The structural properties of the Tröger's base, i.e. chirality, rigidity and curvature, allow for synthetic modifications towards the recognition of different molecules. READ MORE

  7. 25. A three dimensional scaffold for single staged tissue engineering

    Author : Said Zeiai; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Study I. Aims: Evaluate a collagen-PCL scaffold with minced bladder mucosa in vitro. M&M: Minced tissue was cultured on top of the scaffold. Scaffold properties were evaluated. READ MORE