Search for dissertations about: "scale up of pharmaceutical"

Showing result 1 - 5 of 15 swedish dissertations containing the words scale up of pharmaceutical.

2. 1. Multivariate Synergies in Pharmaceutical Roll Compaction : The quality influence of raw materials and process parameters by design of experiments

   Author : Nabil Souihi; Johan Trygg; Jukka Rantanen; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Roll compaction; dry granulation; mannitol; dicalcium phosphate; design of experiments; orthogonal projections to latent structures; critical quality attributes; tablet manufacturing; quality by design; design space; near-infrared chemical imaging; texture analysis; modeling; scale up; instrumented roll; Johanson model;

   Abstract : Roll compaction is a continuous process commonly used in the pharmaceutical industry for dry granulation of moisture and heat sensitive powder blends. It is intended to increase bulk density and improve flowability. READ MORE

4. 2. Pharmaceutical cocrystals : formation mechanisms, solubility behaviour and solid-state properties

   Author : Amjad Alhalaweh; Peter York; Luleå tekniska universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; crystal engineering; cocrystal; formation; solubility; pH; dissolution; surface properties; solid-state properties; Health Science; Hälsovetenskap;

   Abstract : The primary aim of pharmaceutical materials engineering is the successful formulation and process development of pharmaceutical products. The diversity of solid forms available offers attractive opportunities for tailoring material properties. READ MORE

5. 3. Fundamental Investigations of Supercritical Fluid Chromatography

   Author : Martin Enmark; Torgny Fornstedt; Arvind Rajendran; Karlstads universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Supercritical Fluid Chromatography; SFC; Modeling; Adsorption Isotherms; Scale-up; Peak Distortion; Injection; Design of Experiments; Perturbation Peak Method; Elution by Characteristic Points Method; Method transfer; Kemi; Chemistry;

   Abstract : This thesis aims at a deeper understanding of Supercritical FluidChromatography (SFC). Although preparative SFC has started to replace Liquid Chromatography (LC) in the pharmaceutical industry - because of its advantages in speed and its less environmental impact - fundamental understanding is still lacking. READ MORE

6. 4. Towards individualised treatment of tuberculosis

   Author : Katarina Niward; Thomas Schön; Jakob Paues; Judith Bruchfeld; Maria Lerm; Åse B. Andersen; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Each year, around 10 million of individuals develop active tuberculosis (TB). Worldwide, TB is the leading cause of death from an infectious agent surpassing both malaria and HIV. READ MORE

7. 5. Particle Coating in a Wurster Type Bed

   Author : Stina Karlsson; Chalmers tekniska högskola; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Drying; Particle; Tracking technique; Spouted bed; Fluidisation; Multiphase flow; CFD; Trajectory; Coating; Wurster;

   Abstract : The Wurster bed process is frequently used for film coating. In the Wurster bed, particles circulate in the equipment and are sprayed with a liquid which forms a coating when dry. The procedure is repeated until the desired characteristics of the coating layer are obtained. READ MORE