Search for dissertations about: "schizophrenia drugs"

Showing result 1 - 5 of 48 swedish dissertations containing the words schizophrenia drugs.

2. 1. The genetics of schizophrenia : sex, drugs, and cognition

   Author : Elise Koch; Karolina Kauppi; Lars Nyberg; Anders Lundquist; Alessandro Serretti; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; schizophrenia; genetics; cognition; sex differences; polygenic risk; fMRI; network medicine; drug repurposing; precision medicine;

   Abstract : Cognitive impairment constitutes an important predictor of general functional outcomes in schizophrenia. Polygenic risk for schizophrenia has been linked to cognitive ability as well as brain activation during cognitive processing. READ MORE

4. 2. Finding improved drug strategies for schizophrenia : Preclinical studies on lumateperone and sodium nitroprusside

   Author : Joep Titulaer; Åsa Konradsson-Geuken; Anne-Lie Svensson; Erika Roman; Kent Jardemark; Joshua Beckmann; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; schizophrenia; lumateperone; sodium nitroprusside; antipsychotic drugs; Farmaceutisk vetenskap; Pharmaceutical Science; Pharmacology; Farmakologi; Psychiatry; Psykiatri;

   Abstract : Schizophrenia is a severe psychiatric disorder affecting approximately 20 million people worldwide. The disease consists of positive symptoms e.g. hallucinations, negative symptoms such as anhedonia, and cognitive deficits, e. READ MORE

5. 3. Cognitive function studied in animal models of schizophrenia

   Author : Erik Pålsson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; phencyclidine; nitric oxide; prepulse inhibition; latent; nitric oxide; prepulse inhibition; latent inhibition; habituation; NMDA receptor; rat; mouse; cognition; schizophrenia;

   Abstract : Cognitive dysfunction is considered a core deficit of schizophrenia, which currently lacks effective pharmacological treatment. In order to identify novel and more effective drug treatments, translational experimental animal models of cognitive dysfunction are required. Schizophrenia-like symptoms can be induced in humans by phencyclidine (PCP). READ MORE

6. 4. Long-Term Functional Psychosis : Epidemiology in Two Different Counties in Sweden

   Author : Birgitta Widerlöv; Lars von Knorring; Jerker Hetta; Uppsala universitet; []
   Keywords : Psychiatry; epidemiology; functional psychosis; schizophrenia; prevalence; rural-urban gradient; comparative study; antipsychotic drugs; diagnostic criteria; mortality; Psykiatri;

   Abstract : This thesis is based on two independent studies, the first in Stockholm County (index year 1984; n=302), and the second, a replication and validation study, in Uppsala County (index year 1991; n=455).The general aim was to study all individuals with Long-term Functional Psychosis (LFP) within the two counties of Sweden from an epidemiological perspective and to perform specific studies on a subgroup of individuals with schizophrenia. READ MORE

7. 5. Pharmacogenetics and Antipsychotic Treatment in Schizophrenia with Special Focus on Adverse Drug Reactions

   Author : Arzu Gunes; Marja-Liisa Dahl; Maria Gabriella Scordo; Kristina I. Melkersson; Jürgen Brockmöller; Uppsala universitet; []
   Keywords : Medicine; Pharmacogenetics; schizophrenia; antipsychotic treatment; adverse effects; clinical outcome; Medicin;

   Abstract : Genetically determined differences in drug metabolism and disposition and drug targets play a pivotal role in the interindividual variability in the clinical outcome of antipsychotic treatment. The aim of this thesis was to study the impact of polymorphisms in genes involved in the pharmacokinetics and pharmacodynamics of antipsychotics, with special focus on their extrapyramidal and metabolic adverse effects. READ MORE