Search for dissertations about: "schizophrenia immune"

Showing result 1 - 5 of 19 swedish dissertations containing the words schizophrenia immune.

  2. 1. Brain immune mechanisms in schizophrenia : experimental and clinical characterization

    Author : Maximilian Tufvesson Alm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The role of inflammation has become increasingly evident in the pathophysiology of schizophrenia and thought to one of the major causes of the symptoms. Interestingly, immune activation has been linked to the kynurenine pathway of tryptophan degradation, which produces an array of neuroactive metabolites. READ MORE

  4. 2. Gene and pathway associations in neurodevelopmental disorders

    Author : Mitra Etemadikhah; Lars Feuk; Kristiina Tammimies; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gene expression analyses; Neurodevelopmental disorders; Intellectual disability; Schizophrenia;

    Abstract : Neurodevelopmental disorders are complex and heterogenous disorders affecting brain development. In this thesis, we study intellectual disability (ID) and schizophrenia, and we applied genomic, transcriptomic, and proteomic techniques to identify and further investigate candidate variants and important genes and pathways involved in pathology of these two disorders. READ MORE

  5. 3. On the importance of inflammation for personality traits and psychiatric morbidity

    Author : Petra Suchankova; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation; C-reactive protein; complement factor H; S100B; receptor for advanced glycation end products; polymorphism; gene expression; personality traits; suicidal behaviour; schizophrenia; depression; Flinders sensitive line;

    Abstract : Background: Pro-inflammatory mediators have been implicated in processes that could be both beneficial and toxic to cells in the brain. On the one hand balanced levels of these mediators favour e.g. READ MORE

  6. 4. Bridging immune activation with the kynurenine pathway : implications for psychosis

    Author : Markus Larsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Kynurenic acid (KYNA), an endogenous N-Methyl-D-aspartic acid receptor (NMDAR) antagonist, is elevated in patients with schizophrenia. In addition, elevated levels of KYNA are associated with activation of the immune system, which also has been implicated in the development and maintenance of psychotic disorders, including schizophrenia. READ MORE

  7. 5. Cerebrospinal fluid biomarkers in twins with schizophrenia and bipolar disorder

    Author : Viktoria Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Previously identified cerebrospinal fluid (CSF) biomarkers were studied in 37 twins with schizophrenia or bipolar disorder to determine their genetic and environmental properties. Further, comorbidities and sibling risks were investigated in patients with schizophrenia (n=22,781), bipolar disorder (n=30,761) and depression (n=172,479) in relation to multiple sclerosis (MS) (n=16,467) in a nationwide cohort. READ MORE