Search for dissertations about: "scoring function"

Showing result 1 - 5 of 62 swedish dissertations containing the words scoring function.

  2. 1. Peripheral nerve function : metabolic features, clinical assessment, and heat shock protein 27

    Author : Kaveh Pourhamidi; Olov Rolandsson; Lars B Dahlin; Svein-Ivar Mellgren; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Peripheral neuropathy is a common complication among patients with diabetes mellitus, but whether peripheral neuropathy is present in individuals with impaired glucose tolerance (IGT) is debatable. In order to identify and diagnose peripheral neuropathy correctly, it is important to evaluate diagnostic tools that can be implemented in routine health care to assess both large and small nerve fibre function. READ MORE

  4. 2. Computational prediction of receptor-ligand binding affinity in drug discovery

    Author : John Marelius; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; computer-aided ligand design; molecular dynamics simulation; linear interaction energy; free energy perturbation; scoring function; dihydrofolate reductase; thrombin; serine proteases; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molecular Biotechnology; molekylär bioteknik avd f jonfysik ;

    Abstract : The evaluation of inhibition constants or, more generally, receptor-ligand binding affinities is a crucial part of the drug discovery process. Chemical synthesis and affinity screening is only affordable for a limited number of compounds. This makes computational methods to predict binding affinities of candidate ligands highly desirable. READ MORE

  5. 3. Studies on venous function after deep venous thrombosis

    Author : Lena M Persson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : venous plethysmography;

    Abstract : Background: The incidence of deep venous thrombosis (DVT) is estimated to be about 1-2/1000 per year of which approximately 4 % are located in the arm veins. Some of the most important late effects of a DVT are chronic venous dysfunction and the development of post-thrombotic syndrome (PTS). READ MORE

  6. 4. Voice function and quality of life in laryngectomees

    Author : Elisabet Lundström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Individuals who undergo laryngectomy, surgical removal of the larynx, loose their normal voice. The breathing pattern is altered to permanent tracheostomal breathing. A new voice can be established by use of a segment in the lower part of the pharynx and the most upper part of the esophagus, the pharyngo-esophageal (PE) segment. READ MORE

  7. 5. Skin Barrier Function and mRNA Expression Profiles in Patients with Atopic Dermatitis, Ichthyosis Vulgaris, and X-linked Recessive Ichthyosis : Aetiopathogenic Differences and the Impact of Moisturizing Treatment

    Author : Torborg Sturesdotter Hoppe; Berit Berne; Hans Törmä; Anders Vahlquist; Charlotta Enerbäck; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; atopic dermatitis; ichthyosis vulgaris; X-linked recessive ichthyosis; skin barrier function; moisturizers; transepidermal water loss; gene expression; Dermatologi och venereologi; Dermatology and Venerology;

    Abstract : Atopic dermatitis (AD), ichthyosis vulgaris (IV), and X-linked recessive ichthyosis (XLRI) are characterized by dry skin and impaired skin barrier. AD and IV are related to loss-of-function mutations in FLG (encoding filaggrin), whereas XLRI is caused by deletions or inactivating mutations in the steroid sulphatase gene (STS). READ MORE