Search for dissertations about: "secondary metabolites of insulin"
Found 4 swedish dissertations containing the words secondary metabolites of insulin.
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1. Glucose and insulin modulate phagocytosis and production of reactive oxygen metabolites in human neutrophil granulocytes
Abstract : Neutrophil granulocytes play an important role in the host defence against invading microorganisms and constitute the frontline of defence within the innate immune system and are among the first cells to arrive at the site of inflammation. Effective phagocytosis and killing of invading pathogens by neutrophils is of significant importance for successful resistance to infectious diseases. READ MORE
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2. Molecular Imaging of Diabetic Kidney Tissue and Binding Studies of Proinsulin C-peptide
Abstract : Diabetic kidney disease is a serious complication of diabetes with a complex and incompletely understood pathology. In this work, the molecular changes in diabetic rat kidneys at a very early disease stage were studied using nanospray desorption electrospray ionisation mass spectrometry imaging. READ MORE
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3. Protein phosphorylation cascades regulating islet beta-cell insulin exocytosis through glucose sensing and drug signaling : with special focus on serine/threonine protein phosphates and hypoglycemic sulfonylureas
Abstract : In human type 2 diabetes, loss of glucose-sensitive insulin secretion from the pancreatic �-cell is an early pathogenetic event. Initially, this may be compensated for by stimulating insulin secretion by sulfonylurea drugs. READ MORE
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4. Integrating multi-omics for type 2 diabetes : Data science and big data towards personalized medicine
Abstract : Type 2 diabetes (T2D) is a complex metabolic disease characterized by multi-tissue insulin resistance and failure of the pancreatic β-cells to secrete sufficient amounts of insulin. Cells recruit transcription factors (TF) to specific genomic loci to regulate gene expression that consequently affects the protein and metabolite abundancies. READ MORE