Search for dissertations about: "secondary nucleation"

Showing result 1 - 5 of 27 swedish dissertations containing the words secondary nucleation.

  1. 1. Secondary Nucleation in Amyloid Formation

    University dissertation from Lund University, Faculty of Science, Department of Chemistry

    Author : Mattias Törnquist; [2020-05-11]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s disease; amyloid; Ab42; aggregation mechanism; aggregation kinetics; secondary nucleation; Protein misfolding;

    Abstract : Research into Alzheimer's disease is still hampered by a lack of fundamental understanding of the underlying mechanisms. While the aggregation of the amyloid β peptide (Aβ) into amyloid fibrils is highly implicated as a key factor in the disease, the molecular nature of its involvement has proven complex and elusive. READ MORE

  2. 2. Amyloid beta aggregation kinetics : The role of intrinsic and extrinsic factors

    University dissertation from Lund University, Faculty of Science, Department of Biochemistry and Structural Biology

    Author : Xiaoting Yang; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s disease; Abeta; aggregation; kinetics; secondary nucleation;

    Abstract : Cerebral senile plaque is one of the main pathologies of Alzheimer's disease (AD). The amyloid cascade hypothesis suggests that the aggregation of amyloid beta (Abeta) peptide is involved in the pathogenesis of AD, which is supported by the fact that Abeta overexpression or production of more aggregation-prone variants lead to early-onset dementia. READ MORE

  3. 3. Fine Scale Microstructures of Josephson Junctions in YBa2Cu3O7-δ Thin Film Structures

    University dissertation from Lund University, Faculty of Science, Department of Biochemistry and Structural Biology

    Author : Marica Gustafsson; [2000]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; superconductors; thin film evolution; microstructure; nucleation; Josephson junctions; multilayer; YBa2Cu3O7-delta; transmission electron microscopy;

    Abstract : This work concerns the microstructure of YBa2Cu3O7-.delta. (YBCO) and other related thin films in multilayer structures, studied by mainly transmission electron microscopy (TEM). READ MORE

  4. 4. α-Synuclein Fibril Formation and the Effects of Lipid Membranes

    University dissertation from Physical Chemistry, Lund University

    Author : Ricardo Gaspar; [2018-10]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein misfolding; alpha-synuclein; Parkinson s disease; microscopic rate constants; Thioflavin T; ganglioside lipids; Exosomes; protein-lipid co-aggregation; model membranes; monomer-dependent secondary nucleation;

    Abstract : Amyloid protein aggregation results in major disturbances of cellular processes in humans. The most common amyloid-related disorders are Alzheimer´s disease and Parkinson´s disease. Parkinson´s disease is charaterized by the formation of protein-rich aggregates that are deposited in neurons, termed Lewy bodies and Lewy neurites. READ MORE

  5. 5. Molecular investigations of atmospherically relevant interface processes: ice formation and water accommodation on ice and organic surfaces

    University dissertation from Physical Chemistry, Lund University

    Author : Xiangrui Kong; Göteborgs universitet.; Gothenburg University.; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; atmosphere; kinetics; Environmental molecular beam; ice nucleation; supersaturation; accommodation coefficient; phase transition; alcohols; green chemistry;

    Abstract : Clouds and aerosols play important roles in the climate system by affecting on atmospheric chemistry, the radiation budget of the atmosphere, and the water cycle including the formation of precipitation. Climate models with predictive power require quantitative descriptions of aerosols and clouds, but several key processes remain to be fully understood. READ MORE