Search for dissertations about: "secretagogin"
Found 4 swedish dissertations containing the word secretagogin.
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1. Exploring the interactome of EF-hand proteins
Abstract : EF-hand proteins are central in many cellular processes being the main group of Ca2+-sensing and buffering proteins in the cell. In the work presented in this thesis we study ligand interactions of three EF-hand proteins; calmodulin, calbindin D28k and secretagogin. READ MORE
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2. Unravelling protein stability and aggregation
Abstract : Proteins are complex macromolecules that are fundamental to all living species. The stability of proteins are governed by non-covalent forces within the protein and between the protein and its surrounding environment. READ MORE
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3. Calcium-binding proteins as markers and functional determinants of neurons in pain networks
Abstract : The thesis focuses on the anatomical and cellular distribution of three EF-hand calcium binding proteins, secretagogin, neuronal calcium-binding protein 1 (NECAB1) and NECAB2 in dorsal root ganglia (DRGs) and spinal cord of three species, mouse, rat and human, and their possible roles in pathophysiological pain. In Paper I and Paper IV, we report that the expression of secretagogin is limited to a small subpopulation of peptidergic neurons in mouse and human DRGs expressing calcitonin generelated peptide (CGRP). READ MORE
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4. Neuromodulation shapes interneuron communication in the mouse striatum
Abstract : A proper understanding of cognition relies on detailed knowledge about the functional connectivity within and between brain areas. The striatum is generally regarded as the input structure to the basal ganglia, a group of subcortical nuclei that have been demonstrated to be involved in motor function and reward, amongst other functions. READ MORE