Search for dissertations about: "selective kappa opioid receptor"

Found 5 swedish dissertations containing the words selective kappa opioid receptor.

2. 1. Synthesis of Molecular Probes for Exploring the Human Consciousness, 5-HT7 Ligands and Salvinorins

   Author : Pär Holmberg; Anders Karlén; Adolf Gogoll; Anette Johansson; Christer Sahlberg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; serotonin system; opioid system; selective 5-HT7 agonist; 3-aminchromans; salvinorin A; selective kappa opioid receptor; mental disorders; consciousness; regioselective oxidation; enzymatic kinetic resolution; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

   Abstract : In this study, we have addressed the serotonergic and the opioid system within the CNS. Both systems are of outmost importance in the etiology of disease states, especially mental disorders. READ MORE

4. 2. The hippocampal opioid system : role in spatial learning

   Author : Johan Sandin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : opioid; dynorphin; nociceptin; hippocampus; learning; memory; acetylcholine; HPLC; microinjections;

   Abstract : The main aim of the present thesis was to study the role of the endogenous hippocampal opioid system, and in particular, the role of dynorphin B and nociceptin, in spatial learning. The effects of bilateral infusion (using chronic cannulae) of dynorphin B into the dorsal hippocampus (CA3-region), an area containing a high number of dynorphin-containing neurons, were examined in the Morris swim-maze, a spatial task dependent on hippocampal functioning. READ MORE

5. 3. Molecular Mechanisms of Reward and Aversion

   Author : Anna Klawonn; David Engblom; Anders Blomqvist; Paul Kenny; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Motivation; Dopamine; Reward; Aversion; Negative affect; Systemic Inflammation; Drug Addiction; Cytokines; Prostaglandin E2; Melanocortin receptor 4; Acetylcholine; Muscarinic M4 receptor;

   Abstract : Various molecular pathways in the brain shape our understanding of good and bad, as well as our motivation to seek and avoid such stimuli. This work evolves around how systemic inflammation causes aversion; and why general unpleasant states such as sickness, stress, pain and nausea are encoded by our brain as undesirable; and contrary to these questions, how drugs of abuse can subjugate the motivational neurocircuitry of the brain. READ MORE

6. 4. Central pain after spinal cord injury : experimental studies with special emphasis on pharmacological treatment

   Author : Wei Yu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : allodynia; central pain; ischemia; spinal cord injury; intrathecal; opioid; opioid receptors; selective opioid agonists; selective opioid antagonists; tolerance; dependence; clonidine; bovine chromaffin cells; encapsulation; resiniferatoxin;

   Abstract : Injuries and dysfunctions of the central nervous system can cause central pain which, according to clinical experience, is often refractory to conventional treatments. The present thesis consists of experimental studies on the mechanisms and treatments of central pain using a well-established animal model of central pain after spinal cord injury. READ MORE

7. 5. Neurochemical and behavioral studies on ethanol and brain opiod interactions in the brain

   Author : Sara Lindholm; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Substance dependence is a devastating disorder that produces enormous socio-economic costs, personal tragedies and health related problems. The brain mesolimbic dopamine pathway originating in the ventral tegmental area (VTA) with projections to limbic brain structures such as the nucleus accumbens has been implicated in the reinforcing effects of different drugs of abuse. READ MORE