Search for dissertations about: "selective opioid antagonists"

Found 4 swedish dissertations containing the words selective opioid antagonists.

2. 1. Characterization of Substance P (SP) Aminoterminal SP (1-7) Binding in Brain Regions and Spinal Cord of the Male Rat : Studies on the Interaction with Opioid Related Pathways

   Author : Milad Botros; Fred Nyberg; Tsukasa Sakurada; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biological research on drug dependence; Biologisk beroendeforskning;

   Abstract : Binding sites for substance P(1-7), SP(1-7) have been identified and characterized for the first time in crude membrane fraction from rat CNS using tritiated ([3H]) SP(1-7) as tracer. These putative receptors were investigated in relation to their affinity for tachykinins, opioid peptides and sigma receptor ligands. READ MORE

4. 2. Central pain after spinal cord injury : experimental studies with special emphasis on pharmacological treatment

   Author : Wei Yu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : allodynia; central pain; ischemia; spinal cord injury; intrathecal; opioid; opioid receptors; selective opioid agonists; selective opioid antagonists; tolerance; dependence; clonidine; bovine chromaffin cells; encapsulation; resiniferatoxin;

   Abstract : Injuries and dysfunctions of the central nervous system can cause central pain which, according to clinical experience, is often refractory to conventional treatments. The present thesis consists of experimental studies on the mechanisms and treatments of central pain using a well-established animal model of central pain after spinal cord injury. READ MORE

5. 3. Contribution of the sensory nervous system : an experimental study in the rat

   Author : Olle Löfgren; Karolinska Institutet; Karolinska Institutet; []
   Keywords : edema; hindpaw withdrawal latency HWL ; inflammation; microcirculation; scalding; sensory nervous system; sensory neuropeptide antagonists; sensory neuropeptides; thermal injury;

   Abstract : The pathophysiological background to burn induced inflammatory reactions is poorly understood and present therapy options are limited. A model of thermal injury was developed to enable investigations of the acute inflammatory reactions in the periphery as well as of the transmission of nociception at the spinal cord level. READ MORE

6. 4. Neurochemical and behavioral studies on ethanol and brain opiod interactions in the brain

   Author : Sara Lindholm; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Substance dependence is a devastating disorder that produces enormous socio-economic costs, personal tragedies and health related problems. The brain mesolimbic dopamine pathway originating in the ventral tegmental area (VTA) with projections to limbic brain structures such as the nucleus accumbens has been implicated in the reinforcing effects of different drugs of abuse. READ MORE