Search for dissertations about: "selectivity"

Showing result 11 - 15 of 834 swedish dissertations containing the word selectivity.

  2. 11. Novel glycomimetic inhibitors and proteolysis-targeting chimeras for human galectins

    Author : Mujtaba Hassan; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Galectins; Galectin-3; Galectin-8; benzimidazole; affinity; selectivity; X-ray; PROTAC;

    Abstract : Galectins are a family of soluble proteins that bind β-D-galactopyranoside-containing glycoconjugates through their conserved carbohydrate-recognition domains. Galectins have emerged as promising drug targets due to their involvement in various pathological conditions, such as tumor growth and metastasis, autoimmune and inflammatory diseases, as well as metabolic disorders. READ MORE

  4. 12. Beta-Glycosidases from Hyperthermophiles as Biocatalysts

    Author : Therese Hansson; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Bioteknik; Biochemical technology; Biokemisk teknik; Proteins; enzymology; Proteiner; enzymologi; Biotechnology; high temperatures; water activity; activity; selectivity; hexanol; hexyl-b-glycoside; galacto-oligosaccharides; lactose; hyperthermostable b-glycosidase; hydrolysis; optimisation; transglycosylation;

    Abstract : The thesis concerns glycosyl transfer with use of b-glycosidases, most of them from hyperthermophilic organisms. Both optimisation of the reaction conditions and protein engineering in terms of site-directed mutagenesis were used to improve b-glycosidase-catalysed reactions. READ MORE

  5. 13. Selection of transthyretin amyloid inhibitors

    Author : Irina Iakovleva; Anders Olofsson; Göran Larsson; Bente Westergaard; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transthyretin; TTR; ATTR; TTR-stabilizing drugs; selectivity; medicinsk biokemi; Medical Biochemistry;

    Abstract : Amyloidosis is a group of clinical disorders caused by the aggregation of specific proteins into abnormal extracellular deposits. Today, 31 different proteins have been linked to amyloid diseases including transthyretin-related amyloidosis (ATTR). READ MORE

  6. 14. Enzyme catalysis towards bio-based UV-curable buildingblocks

    Author : Maja Finnveden; Mats Martinelle; Katja Loos; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Enzyme; Enzymatic Polymerizations; Biocatalysis; Lipase; CalB; MsAcT; Substrate specificity; Selectivity; Polymer Chemistry; UV-curring; Bioteknologi; Biotechnology;

    Abstract : Polymeric materials are found in virtually all areas of daily life; they are found in everything from packages keeping our food safe to the buildings where we spend our days, and the production is a worldwide industry. Although polymeric materials play a big part in sustainable solution’s, a lot can be done to develop more environmental methods for producing them. READ MORE

  7. 15. Atomic layer epitaxy of copper

    Author : Per Mårtensson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Atomic Layer Epitaxy; ALE; copper; ab initio calculations; DFT; CuCl; Cu thd 2; selectivity; Kemi; Chemistry; Kemi; Inorganic Chemistry; oorganisk kemi;

    Abstract : The high electric and thermal conductivity of copper has made it to a prime candidate as interconnect material in future integrated circuits. In this thesis, Atomic Layer Epitaxy has been used to deposit thin copper films on a variety of substrates, using both CuCl and Cu(II)2,2,6,6-tetramethyl-3,5-heptanedionate, Cu(thd)2, as precursors and hydrogen as reducing agent. READ MORE