Search for dissertations about: "senile"
Showing result 1 - 5 of 52 swedish dissertations containing the word senile.
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1. Senile cardiac amyloidosis
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2. Transthyretin in senile systemic amyloidosis and familial amyloidotic polyneuropathy
Abstract : The amyloidoses comprise a heterogeneous group of disorders characterized by the deposition of fibrillar, proteinaceous amyloid deposits in various organs and tissues. To date, 17 different proteins of various sizes have been identified as amyloid proteins. READ MORE
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3. Clinical studies and chemical pathology in normal aging and dementia of Alzheimer type
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4. Apolipoprotein A-IV and Transthyretin in Swedish Forms of Systemic Amyloidosis
Abstract : Over 20 different plasma proteins have been shown to have the capacity to undergo conformational changes and self-assemble into highly stable and insoluble amyloid fibrils. One, transthyretin (TTR), consists of 127 amino acid residues arranged in eight β-strands (named A to H) and is involved in two different clinical forms of amyloidosis. READ MORE
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5. Targeting Early Stages of Alzheimer’s Disease in a Transgenic Model
Abstract : The Arctic mutation causes early-onset Alzheimer’s disease (AD), and makes amyloid-β (Aβ) peptides more prone to form Aβ protofibrils. The aims of this thesis were to investigate the mechanisms of the Arctic mutation in vivo, and to use transgenic models to determine the role of early intermediates of Aβ aggregation, like protofibrils, in the pathogenesis. READ MORE