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Showing result 1 - 5 of 23 swedish dissertations matching the above criteria.

  2. 1. Aspects on sepsis : treatment and markers

    Author : Anna Gustafsson; Malmö högskola; []
    Keywords : antimicrobial peptides; cytokines; lipoteichoic acid; lipopolysaccharide; soluble urokinase plasminogen activator receptor; sepsis;

    Abstract : Sepsis is one of the greatest challenges in critical care medicine today, while the treatment of sepsis and evaluation of its severity is complicated. The first part of this thesis presents two approaches on the use of antimicrobial peptides in sepsis treatment, relying on both soluble and immobilized peptides. READ MORE

  4. 2. Unraveling the immune response in sepsis and meningitis. Diagnostic and therapeutic approaches

    Author : Jane Fisher; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; meningtis; sepsis; neutrophil extracellular traps NETs ; glymphatic system; DNase; pneumococci;

    Abstract : Severe infections continue to constitute a large burden, with high mortality and risk of sequelae. Sepsis is a dysregulated host response to an infection that causes life threatening organ damage. Meningitis is a severe infection of the brain that often leads to sepsis and death or lasting neurological damage. READ MORE

  5. 3. Avian antibodies applied in particle enhanced turbidimetric immunoassay : Developement of serum/plasma calprotectin immunoassay and its clinical performance as a marker for bacterial infections

    Author : Tom Nilsen; Anders Larsson; Bjørn Steen Skålhegg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sepsis; avian antibodies; calprotectin antigen; particle enhanced turbidimetric immunoassay.; Clinical Chemistry; Klinisk kemi;

    Abstract : Calprotectin is a cytosolic protein in the granulocytes, consisting of S100A8 and S100A9. On the site of inflammation, the neutrophils release the cytosol as an inflammatory response. The circulating calprotectin concentration increases and can therefore be used as marker for neutrophil activation and inflammation. READ MORE

  6. 4. Biomolecules at Interfaces -Studied by Surface and Solution Techniques

    Author : Anna Bergstrand; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; LDL; sepsis; PEG; LPS; lipopolysaccharide; QCM-D; SPR;

    Abstract : The interfacial behaviour of biomolecules in general and proteins in particular is interesting from a biochemical point of view since proteins are involved in processes such as complement activation, blood coagulation and atherosclerotic plaque formation, but also in the context of biomedical applications such as solid-phase diagnostics, therapeutic aphaeresis and biosensors. The objective of this thesis is to study biomolecular interactions using surface sensitive biosensor techniques such as surface plasmon resonance, SPR, in combination with bulk techniques. READ MORE

  7. 5. Timing Matters : Wounding and entomopathogenic nematode infection kinetics

    Author : Alexis Dziedziech; Ulrich Theopold; Angela Giangrande; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drosophila melanogaster; Heterorhabditis bacteriophora; Photorhabdus luminescens; entomopathogenic nematodes; worms; high-resolution microscopy; time-lapse; infection; kinetics; sepsis; septic wounding; injury; clotting; glutactin; transglutaminase; prophenoloxidase; cell death; pyroptosis; caspase; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Over time, insects have developed complex strategies to defend themselves against presenting threats. However, in the evolutionary arms race of survival, pathogens have adapted to quickly overcome the immune response mounted by the host. READ MORE