Search for dissertations about: "sequence binding motif"

Showing result 16 - 20 of 79 swedish dissertations containing the words sequence binding motif.

  2. 16. Structural Study of the WH2 Family and Filamin: Implications for Actin Cytoskeleton Regulation

    Author : Adeleke H. Aguda; Robert Robinson; Lars Rask; Lars Backman; Uppsala universitet; []
    Keywords : Biochemistry; Actin; Thymosin; Ciboulot; N-WASP; Filamin; Calponin homology domain; WH2; Protein Crystallography; Biokemi;

    Abstract : Cellular processes like motility, chemotaxis, phagocytosis and morphogenesis are dependent on the dynamic regulation of the actin cytoskeleton. This cytoskeleton system is tightly controlled by a number of diverse actin-binding proteins (ABPs) by various mechanisms described as nucleation, polymerization, capping, severing, depolymerization and sequestration. READ MORE

  4. 17. Modelling of melanocortin receptors and their ligands

    Author : Peteris Prusis; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; melanocortin; G-protein coupled receptor; modeling; three-dimensional; QSAR; chemometrics; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Abstract : Five subtypes of melanocortin receptors (MC1-MC5R) mediate a wide range of physiological actions, including control of skin tanning, inflammation and food intake. The natural ligands for these receptors are the melanocortins, which are linear peptides 11 to 39 amino acids long. READ MORE

  5. 18. Molecular basis and pharmacological implications of Alzheimer amyloid ß-peptide fibril formation

    Author : Lars Tjernberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alzheimer s disease; amyloid; fibrils; inhibitor; protease resistance; electron microscopy; fluorescence correlation spectroscopy.;

    Abstract : Alzheimer's disease is a progressive neurodegenerative disease, mostly affecting elderly. The invariable deposition of protease-resistant fibrils of Alzheimer amyloid ß-peptide (Aß) in the parenchyma and blood vessels of the brain is a central event. READ MORE

  6. 19. The immunoglobulin heavy chain 3ʼ enhancer : coupling of basic-Helix-Loop-Helix proteins to the regulation of enhancer function

    Author : Velmurugesan Arulampalam; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : During B lymphocyte development, the transcriptional activity of the IgH locus is subject to spatial and temporal changes. One cis-control element, the IgH 3' enhancer, has been implicated in regulating functional events in late B cell development. READ MORE

  7. 20. Characterization of the Alzheimer's disease-associated clac protein

    Author : Linda Söderberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer's disease (AD) is the most prevalent form of dementia in elderly people and is neuropathologically characterized by the presence of extracellular senile plaques (SPs) in the brain. SPs are mainly composed of the amyloid beta-peptide (Abeta), proteolytically derived from the amyloid beta-precursor protein by sequential cleavages performed by beta- and gammasecretase, to generate Abeta species of 40 and 42 amino acids, respectively. READ MORE