Search for dissertations about: "sequence selectivity"
Showing result 1 - 5 of 56 swedish dissertations containing the words sequence selectivity.
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1. Serine Hydrolase Selectivity : Kinetics and applications in organic and analytical chemistry
Abstract : The substrate selectivities for different serine hydrolases were utilized in various applications, presented in papers I-VI. The articles are discussed in the thesis in view of the kinetics of the enzyme catalysis involved. READ MORE
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2. Kinetic Recognition of Nucleic Acids - Studies on the DNA Binding Selectivity of Threading Ruthenium Complexes
Abstract : Despite the great progress in our understanding of DNA during the past half-century, there are many important aspects of its chemical and biological role yet to be explored. The principles by which it selectively interacts with other molecules have attracted much interest due to the relevance for fundamental cellular processes, as well as for the development of diagnostic probes and effective pharmaceutical agents. READ MORE
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3. Structural Requirements for Selective DNA Binding - Studies on Mono- and Binuclear Ruthenium Complexes
Abstract : Ever since the discovery of the role of DNA as the template for protein synthesis, efforts have been made to develop DNA targeted drugs. One of the major challenges in the design of DNA binding drugs is to achieve selective binding to specific DNA sequences, which is crucial to avoid side effects. READ MORE
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4. DNA Interaction Dynamics of Ruthenium(II) Complexes
Abstract : DNA-binding of small synthetic ligands is of great importance in a number of different applications, from medicine to molecular biology. This thesis focuses on interactions between DNA and ruthenium(II) complexes, in particular the dimers [µ-bidppz(L)4Ru2]4+ (L=1,10-phenanthroline (P) or L=2,2-bipyridine (B)). READ MORE
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5. Selectivity of dopamine D1 and D2 receptor agonists – A combined computational approach
Abstract : Dopamine (DA) is an endogenous neurotransmitter acting in the central nervous system. DA plays a key role in many vital brain functions such as behavior, cognition, motor activity, learning, and reward. Dopamine receptors belong to the rhodopsin like family of G-protein coupled receptors (GPCRs). READ MORE
