Search for dissertations about: "sequence signatures"

Showing result 1 - 5 of 25 swedish dissertations containing the words sequence signatures.

  2. 1. Genomic signatures in viruses

    Author : Joel Gustafsson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Virus evolution; Bioinformatics; Markov Chains; Genomic signatures;

    Abstract : In an age of global pandemics, studying how viruses and their genomes evolve is of great importance. It has previously been found that the genomes of many eukaryotes and prokaryotes have specific preferences for nucleotides, dinucleotides, and codons. READ MORE

  4. 2. Computational studies of mutational sequence signatures in cancer genomes

    Author : Markus Lindberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Genomcis; Mutational signatures; Ultraviolet light; Multifocal tumors;

    Abstract : Cancer typically forms when mutational processes modify key cancer driver genes, resulting in positive selection and tumor growth. As such, mutational processes are at the core of the disease. Trinucleotide mutational signatures have emerged in the last decade as essential tools for analysis of mutational processes. READ MORE

  5. 3. Interpreting a Giant : Studies of Structure and Function of Tripeptidyl-peptidase II

    Author : Sandra Eklund; Birgitta Tomkinson; Beate Rockel; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Tripeptidyl-peptidas II; molecular ruler; sequence signatures; pH-dependence; endopeptidase; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Abstract : Tripeptidyl-peptidase II (TPP II) is a subtilisin-like serine peptidase that forms a gigantic homooligomeric complex, and is involved in the degradation of peptides in the cytosol. In addition, TPP II has been implicated in specific cellular processes, such as apoptosis control and adipogenesis, but if this is dependent on its endo- or exopeptidase activity remains to be determined. READ MORE

  6. 4. Arrayed identification of DNA signatures

    Author : Max Käller; Lundeberg Joakim; Mats Nilsson; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; apyrase; allele-specific extension; competitive hybridization; DNA sequencing; genotyping; human papillomavirus HPV ; MC1R; microarray; mutation; p53; protease; Bioengineering; Bioteknik;

    Abstract : In this thesis techniques are presented that aim to determine individual DNA signatures by controlled synthesis of nucleic acid multimers. Allele-specific extension reactions with an improved specificity were applied for several genomic purposes. Since DNA polymerases extend some mismatched 3’-end primers, an improved specificity is a concern. READ MORE

  7. 5. Predicting the route: from protein sequence to sorting in eukaryotic cell

    Author : Marco Salvatore; Arne Elofsson; Norman Davey; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; eukaryotic cell; sorting signals; subcellular localisation; machine learning; biological sequence analysis; bioinformatics; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Abstract : Proteins need to be localised in the correct compartment of a eukaryotic cell to function correctly. Therefore, a protein needs to be transported to the right location. Specific signals present in the protein sequence direct proteins to different subcellular localisations. READ MORE