Search for dissertations about: "sequence similarity"

Showing result 1 - 5 of 141 swedish dissertations containing the words sequence similarity.

  2. 1. Deciphering sequence data : A multivariate approach

    Author : Maria Sandberg Hiltunen; Michael Sjöström; Svante Wold; Lars Ståhle; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Principal properties; amino acids; nucleotides; tRNA; DNA; multivariate data analysis; sequence analysis; QSAR; quantitative sequence activity relationships;

    Abstract : In this thesis, attention has been focused on the quantitative description of nucleic acids, proteins and peptides. The strategy was to use multivariate chemometrical methods for improving the understanding of the complex structural codes of these kinds of biological molecules. READ MORE

  4. 2. Selection of antigens for antibody-based proteomics

    Author : Lisa Berglund; Mathias Uhlén; Sören Brunak; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; epitope; antigen; antibody; affinity; protein; proteome; proteomics; bioinformatics; prediction; primer design; sequence similarity; Bioengineering; Bioteknik;

    Abstract : The human genome is predicted to contain ~20,500 protein-coding genes. The encoded proteins are the key players in the body, but the functions and localizations of most proteins are still unknown. READ MORE

  5. 3. The use of structural information to improve biological sequence similarity searches

    Author : Jeanette Tångrot; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioinformatik; Hidden Markov Model; HMM; protein structure alignment; protein structure superimposition; remote homologue; FISH-server; protein annotation; Bioinformatics; Bioinformatik;

    Abstract : Bioinformatics is a fast-developing field that make use of computational methods to analyse and structure biological data. An important branch of bioinformatics is structure and function prediction of proteins. To determine the structure of a protein is a crucial part in the characterisation of the molecule. READ MORE

  6. 4. From protein sequence to structural instability and disease

    Author : Lixiao Wang; Uwe Sauer; Sven Hovmöller; Umeå universitet; []
    Keywords : protein domain; remote homologue; intrinsically disorder unstructured proteins; protein function; point mutation; protein family protein stability; HMMs; CRFs; SVMs;

    Abstract : A great challenge in bioinformatics is to accurately predict protein structure and function from its amino acid sequence, including annotation of protein domains, identification of protein disordered regions and detecting protein stability changes resulting from amino acid mutations. The combination of bioinformatics, genomics and proteomics becomes essential for the investigation of biological, cellular and molecular aspects of disease, and therefore can greatly contribute to the understanding of protein structures and facilitating drug discovery. READ MORE

  7. 5. Physical Modeling of Protein Folding

    Author : Stefan Wallin; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; relativity; quantum mechanics; classical mechanics; three-helix bundle; similarity measure; Mathematical and general theoretical physics; protein dynamics; protein folding; two-state; Matematisk och allmän teoretisk fysik; thermodynamics; statistical physics; gravitation; klassisk mekanik; kvantmekanik; relativitet; statistisk fysik; termodynamik; Fysicumarkivet A:2003:Wallin;

    Abstract : Sequence-based models for protein folding are developed and tested on peptides with both alpha- and beta-structure, and on small three-helix-bundle proteins. The interaction potentials of the models are minimalistic and based mainly on hydrogen bonding and effective hydrophobicity forces. READ MORE