Search for dissertations about: "sequence variability"

Showing result 1 - 5 of 99 swedish dissertations containing the words sequence variability.

  2. 1. Statistical assessment of somatic mutations and genomic variability using DNA sequence data

    Author : Anna Rehammar; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA sequence data; exome sequencing; calling of somatic mutations; metagenomics; hierarchical Bayesian model; genomic variability; calling of somatic mutations;

    Abstract : The development of new DNA sequencing techniques have made it possible to generate high-resolution genomic data at an unprecedented pace. However, the high dimensionality in combination with the substantial levels of technical errors and biological variability make the analysis challenging. READ MORE

  4. 2. Glycoprotein G of Herpes simplex virus type 2. Antigenicity and genetic variability

    Author : Jan-Åke Liljeqvist; Göteborgs universitet; []
    Keywords : Herpes simplex virus type 2; glycoprotein G; antigenic regions; sequence variability;

    Abstract : Herpes simplex virus type 2 (HSV-2) causes genital lesions, meningitis and occasionally, severe neonatal infections. Globally HSV-2 infection is one of the most common sexually transmitted diseases. READ MORE

  5. 3. Interindividual Variability of Drug Transport Proteins : Focus on Intestinal Pgp (ABCB1) and BCRP (ABCG2)

    Author : Gunilla Englund; Per Artursson; Håkan Melhus; Andreas Kindmark; Joseph W Polli; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; membrane transport proteins; ATP-Binding Cassette Transporters; P-glycoprotein; Breast Cancer Resistance Protein; Interindividual variability; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Abstract : The appearance of adverse drug reactions is a common reason for hospitalization in Western countries. Research on underlying biological mechanisms for interindividual variability in drug response aims to better identify patients with exceptional genetic traits, disease conditions or risk of drug-drug interactions and thereby help to prevent adverse drug reactions. READ MORE

  6. 4. Streptococcal M protein and human C4BP

    Author : Jenny J Persson; Avdelningen för medicinsk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Infektioner; Infections; Medicin människa och djur ; Medicine human and vertebrates ; human C4BP; M protein; antigenic variation; sequence variability; Streptococcus pyogenes; innate immunity;

    Abstract : Antigenic variation of surface proteins allows microorganisms to evade the immune system of the infected host. This phenomenon represents an apparent paradox, because the variable protein must retain an important function, while its antigenic properties vary extensively. READ MORE

  7. 5. Implications of Local Puumala Hantavirus Genetics and Epidemiology for Diagnostics and Vaccine Development

    Author : Patrik Johansson; Fredrik Elgh; Göran Bucht; Detlev Krüger; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Communicable diseases; hantavirus; Puumala virus; nephropathia epidemica; genome sequence; glycosylation; linear DNA vaccine; microarray; identification; genetic variability; Infektionssjukdomar; Infectious diseases; Infektionssjukdomar; medicinsk virologi; Medical Virology;

    Abstract : Puumala viruses, a member of the Hantavirus genus in the Bunyaviridae family, are enveloped by a lipid bilayer and possesses a tripartite single stranded RNA genome with negative polarity. The hantaviruses encode four proteins: a nucleocapsid protein (N), two membrane spanning glycoproteins (GN and GC) and a RNA dependent RNA polymerase (RdRp). READ MORE