Search for dissertations about: "sequencing"
Showing result 26 - 30 of 1401 swedish dissertations containing the word sequencing.
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26. Next generation molecular diagnostics using ultrasensitive sequencing
Abstract : Massively parallel sequencing enables the exploration of the genetic heterogeneity within microbial, viral and tumor cell populations. Detecting circulating tumor DNA in blood and other body fluids has the potential to revolutionize molecular diagnostics. READ MORE
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27. Whole Genome Sequencing of Enterotoxigenic Escherichia coli
Abstract : Enterotoxigenic Escherichia coli (ETEC) infections are a common cause of diarrhea but little is known about the evolution and genomic composition of ETEC. The main aim of this thesis was to generate a large collection of whole genome sequenced ETEC isolates to study the evolution of such bacteria on a global level and to search for novel colonization factors (CFs) using both classical and cutting-edge genomic techniques. READ MORE
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28. Software Tools and Algorithms for Shotgun Sequence Assembly
Abstract : During the last ten years, a genomics revolution has changed the ways biological research is carried out. The draft sequence of the human genome is available, as well as the sequence of 84 other completed genomes. READ MORE
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29. Somatic Mutations in Breast Cancer Genomes : Discovery and Validation of Breast Cancer Genes
Abstract : Breast cancer is the most common cancer in women worldwide. However, the genetic alterations that lead to breast cancer are not fully understood. This thesis aims to identify novel genes of potential mechanistic, diagnostic or therapeutic interest in breast cancers by mutational analysis and whole-genome sequencing. READ MORE
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30. Towards spatial host-microbiome profiling
Abstract : Sequencing technologies and applications have pushed the limits and enabled novel studies of biological mechanisms, evolutionary relationships and communication networks between cells. The technical developments leading to single cell RNA-sequencing have enabled detection of rare cell populations while spatial resolution added insights into larger biological environments, like tissues and organs. READ MORE