Search for dissertations about: "sequencing"

Showing result 41 - 45 of 1406 swedish dissertations containing the word sequencing.

  2. 41. Ultrasensitive Molecular Monitoring of Breast Cancer and Acute Myeloid Leukemia

    Author : Yilun Chen; Translational Oncogenomics; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; AML; PTEN; PI3K; Liquid biopsy; Sequencing; cfDNA; ctDNA; Structural variants; Mammography; CTC; Mutation detection; IBSAFE; MRD;

    Abstract : Cancer is the common name to a group of biologically diverse malignant neoplastic diseases. Approximately 18 million people are diagnosed with cancer annually and 8.8 million patients die from it. Tumorigenesis and progression of cancer are driven by alterations in the cancer cell genome. READ MORE

  4. 42. Solid-phase Proximity Ligation Assays : High-performance and multiplex protein analyses

    Author : Spyros Darmanis; Masood Kamali-Moghaddam; Ulf Landegren; Mathias Uhlen; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; proximity ligation assay; multiplexed; biomarkers; solid-phase; microparticles; cancer; sequencing; Molecular biology; Molekylärbiologi; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : Protein biomarkers circulating in blood hold the promise of improved diagnosis, prognosis and follow-up of treatment of disease via minimally invasive procedures. For the discovery and validation of such biomarkers, methods are needed that can facilitate parallel, highly specific and in-depth analysis of the blood proteome. READ MORE

  5. 43. miRNA and Asymmetric siRNA : Small RNAs with Large Effects on Bone Metabolism

    Author : Navya Laxman; Andreas Kindmark; Sara Windahl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; miRNA; cp-siRNA; RNAi; bone; Osteoblast; Sequencing; Differential expression; Wnt pathway; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : RNA interference (RNAi) is a post-transcriptional gene silencing process elicited by double-stranded RNA, such as micro-RNA (miRNA) and small interfering RNA (siRNA). They are 18-25 nucleotide long, small non-coding RNAs acting as critical regulators in eukaryotic genome expression. READ MORE

  6. 44. Proteome Profiling of Strawberry and Characterization of a Bet v 1-Homologous Allergen

    Author : Rikard Alm; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; metabolism; Biochemistry; Metabolism; Biokemi; Naturvetenskap; Plant biochemistry; Växtbiokemi; Respiratory system; Andningsorganen; Natural science; biomatematik; Bioinformatics; medical informatics; biomathematics biometrics; Bioinformatik; medicinsk informatik; speclust; proteios; biological variation; phenotypic plasticity; data management; DIGE; sequencing; isoform; allergen; Proteomics; strawberry;

    Abstract : Strawberry (Fragaria ananassa) is an economically important crop, and recognised as an important source of antioxidants and bioactive compounds with health promoting effects. Yet increased incidence of allergy puts a limit to the choice of food for an increasing percentage of the population. READ MORE

  7. 45. Gastrointestinal stromal tumors. Pathogenetic mechanisms, phenotypic characterization and prognosis

    Author : Johanna Andersson; Göteborgs universitet; []
    Keywords : Gastrointestinal stromal tumor GIST ; neurofibromatosis type I NF1 ; mutation; prognosis; denaturating high performance liquid chromatography dHPLC ; sequencing; KIT; PDGFRA; NF1;

    Abstract : Gastrointestinal stromal tumor (GIST), the most common non-epithelial neoplasm of the gastrointestinal tract, has historically been problematic both conceptually and clinically. Recently, GIST has been shown to share phenotypic features with the interstitial cells of Cajal (ICC), including the almost uniform expression of the tyrosine kinase receptor KIT. READ MORE