Search for dissertations about: "sera"

Showing result 1 - 5 of 267 swedish dissertations containing the word sera.

2. 1. Recognition molecules of the complement system: C1q and mannan-binding lectin in autoimmunity and immune defence

   Author : Ulla Mårtensson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; serologi; Immunologi; Immunology; serology; autoantibodies; collectins; complement; autoimmunity; Infections; Infektioner;

   Abstract : The C1 subcomponent C1q and the mannan-binding lectin (MBL) are recognition proteins of the complement system, and have similar structure. C1q binds to IgG and IgM and activates the classical pathway. MBL binds to carbohydrate structures and activates the lectin pathway. READ MORE

4. 2. Antigens and antibodies involved in humoral immunity to plasmodium falciparum

   Author : Mats Wahlgren; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Malaria plasmodiidae cause more death and disease than any other known human pathogen. The parasite still threatens half of the world population {2.5 billion) and 300 million people are considered to become infected every year. READ MORE

5. 3. Apolipoprotein CIII and Ljungan virus in diabetes

   Author : Rebecka Holmberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : It has been shown that there are patients with type 1 diabetes (T1D), whose sera induce an increased activity of voltage-gated Ca2+-channels in pancreatic beta-cells, resulting in increased cytoplasmic free Ca2+ concentration ([Ca2+]i) and apoptosis. Purification of the protein in the active fraction of T1D sera revealed that the observed effects were mediated by apolipoprotein CIII (apoCIII), and this protein was shown to be increased in serum from T1D patients. READ MORE

6. 4. Serum proteins in type 1 diabetes

   Author : Nancy Dekki Wenna; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : We have previously shown that there are patients with type 1 diabetes T1D whose sera interfere with cytoplasmic free Ca2+-concentration ([Ca2+]i), resulting in �-cell apoptosis. In this study the frequency of sera, that induces this effect, was found to be around 35% in T1D patients, and 25% in first degree relatives (FDR) of T1D patients. READ MORE

7. 5. Superantigens in group A streptococcus : gene diversity and humoral immune response

   Author : Linda Maripuu; Mari Norgren; Susan Hollingshead; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Group A streptococcus; Streptococcus pyogenes; superantigen SAg ; SAg-gene profile; M-protein; emm-genotype; biomedicinsk laboratorievetenskap; biomedical laboratory science;

   Abstract : Group A streptococcus (GAS) is a strictly human pathogen that causes infections ranging from asymptomatic carriage to the highly lethal streptococcal toxic shock syndrome (STSS). GAS are classified according to the sequence of the variable 5’ end of the emm-gene that encodes the surface associated M-protein. READ MORE