Search for dissertations about: "serglycin"
Found 5 swedish dissertations containing the word serglycin.
-
1. Mast Cells as Sentinels : Role of serglycin and mast cell proteases in infection and inflammation
Abstract : Mast cells (MCs), normally classified into connective tissue MCs and mucosal MCs, are highly granulated cells found in the interface between the interior and the exterior environment of our body, e.g. skin, airways and gastro-intestinal tract. READ MORE
-
2. Serglycin-dependent mast cell-specific proteases and their potential interactions with Giardia intestinalis
Abstract : Mast cells are located in mucosal and connective tissues throughout the body where they play important roles in immune reactions towards infections. Mast cell deficiency results in failure of clearance of the non-invasive intestinal protozoan parasite Giardia intestinalis in mice, but the mast cell-driven mechanisms remain poorly understood. READ MORE
-
3. The response of mast cells and serglycin-dependent proteases to parasitic infection : studies on mast cells during Toxoplasma gondii (murine) and Dictyocaulus vivparus (bovine) infection
Abstract : The proteoglycan (PG), serglycin (SG), is expressed in several hematopoietic cells and studies of the SG knockout mice (SG-/-) revealed prominent effects on the storage of certain mouse mast cell proteases (mMCPs) such as mMCP-4, -5 and -6.In this thesis, the role of SGPG during parasitic infection was addressed. READ MORE
-
4. The role of mast cell proteases in allergic disease and apoptosis
Abstract : Mast cells (MCs) are key effector cells in allergic reactions, through the release of a wide variety of granule-stored and de novo synthesized inflammatory mediators. The MC secretory granules contain exceedingly high levels of serglycin proteoglycan and the heparin-binding proteases chymase, tryptase and carboxypeptidase A. READ MORE
-
5. Complement in Disease - Extracellular Proteins as Complement Regulators
Abstract : Complement activation occurs during inflammatory joint diseases such as rheumatoid arthritis (RA) and is thought to contribute to the chronic inflammation observed within the joints. Previous studies have shown that certain cartilage components of the small leucine-rich repeat protein (SLRP)-family regulate complement activity, thereby possibly contributing to disease progression. READ MORE