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Found 3 swedish dissertations matching the above criteria.

2. 1. Dynamics of the Bacterial Genome : Rates and Mechanisms of Mutation

   Author : Sanna Koskiniemi; Dan Andersson; Diarmaid Hughes; Ivan Matic; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bacteria; bacterial evolution; genome reduction; gene loss; serial passage; DNA homology; tranlesion DNA polymerase; stress; Microbiology; Mikrobiologi; Bacteriology; Bakteriologi; Evolutionary Genetics; Evolutionär genetik; Mikrobiologi; Microbiology;

   Abstract : Bacterial chromosomes are highly dynamic, continuously changing with respect to gene content and size via a number of processes, including deletions that result in gene loss. How deletions form and at what rates has been the focus of this thesis. In paper II we investigated how chromosomal location affects chromosomal deletion rates in S. READ MORE

4. 2. Evolution of New Genes and Functions

   Author : Erik Lundin; Dan I Andersson; Joakim Näsvall; Diarmaid Hughes; Arjan de Visser; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

   Abstract : To answer major evolutionary questions, we need a better understanding of the effects of mutations on specific functions and organism fitness. The aim of this thesis was to elucidate how new functions evolve and potential trade-offs with the original function. READ MORE

5. 3. Genetic analysis of human astrocytic gliomas : xenografts as a research tool

   Author : Helena M Goike; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Cancer is a genetic disorder of somatic cells. An accumulation of genetic changes is believed to result in neoplastic transformation and malignant progression. In humans, astrocytic gliomas are the most common primary tumors of brain tissue. They are malignancy graded according to World Health Organization criteria. READ MORE