Search for dissertations about: "serological research"

Showing result 1 - 5 of 27 swedish dissertations containing the words serological research.

  2. 1. Leishmaniasis in Sweden. Molecular, diagnostic and epidemiological studies of the parasite Leishmania in a non-endemic country

    Author : Sara Karlsson Söbirk; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; leishmaniasis; Parasite; Epidemiological studies; Serology; diagnostic method; Immune System; Sweden; leishmaniasis; Leishmania; immune system; chitinase; CAZy; Immune evasion; Antimicrobial peptide AMP ; Chemokine; epidemiology; Sweden; Serological assays; diagnostic method;

    Abstract : This doctoral thesis consists of four separate papers, in which we; investigate epidemiological and clinical aspects of leishmaniasis in Sweden in order to increase awareness of the disease, elucidate some aspects of the interaction of the parasite and the human immune system and validate serological tools as a complement for diagnosis of leishmaniasis.. READ MORE

  4. 2. Viral proteins as serological antigens - Development and clinical applications

    Author : Linn Persson Berg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Serology; ELISA; IgG; Varicella-zoster virus; Epstein-Barr virus; Measles virus; Viral glycoproteins; Multiple sclerosis;

    Abstract : Serological methods are based on the detection of antibodies and antigens in mainly serum but also in other body fluids such as cerebrospinal fluid (CSF). Conventional whole virus antigens are widely used in viral serological assays. READ MORE

  5. 3. Advanced molecular tools for diagnostic analyses of RNA and antibodies in situ and in solution

    Author : Mengqi Wang; Ulf Landegren; Anders Ståhlberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Homogenous serological assay; PCR-based antibody detection; Proximity extension assay; SARS-CoV-2 antibody; Extracellular vesicles; Proximity barcoding assay; in situ superRCA; mutant transcript;

    Abstract : Advanced molecular diagnostics uses in vitro biological assays to detect nucleic acids or proteins even in low concentrations across samples, allowing for the identification of biomarkers, monitoring the course of the disease over time, and selection of appropriate therapy. In this thesis, I focus on development and early applications of several molecular tools of expected value in research, and eventually also clinically. READ MORE

  6. 4. HIV-1 infection and loss of serological memory : the role of altered expression of B-cell chemokine receptors, timing of HAART and impaired antibody affinity maturation

    Author : Alberto Cagigi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Currently, big efforts in HIV-1 research are devoted to the design of a HIV-1 vaccine. However, no successful vaccine is yet available, also due to the lack of basic knowledge in HIV-1 pathogenesis which is still profound. READ MORE

  7. 5. Screening Detected Celiac Disease in Children

    Author : Charlotta Webb; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Celiac disease; screening; prevalence; small-bowel biopsy; enteropathy; transglutaminase; gluten-free diet; adherence;

    Abstract : Background: The prevalence of celiac disease (CD) is estimated to be around 1%, but most CD cases are undiagnosed. Sweden experienced an epidemic of clinically detected celiac disease in children younger than 2 years of age, partly due to changes in infant feeding practices, were the amount of gluten and age at introduction was changed. READ MORE