Search for dissertations about: "serum albumin adducts"

Showing result 1 - 5 of 8 swedish dissertations containing the words serum albumin adducts.

  2. 1. Protein adducts of hexahydrophthalic anhydride- chemical structures and biomarkers

    Author : Monica Kåredal; Avdelningen för arbets- och miljömedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; arbetsmiljömedicin; Yrkesmedicin; industrial medicine; Occupational health; nasal lavage; mass spectrometry; biomarker; human serum albumin; hemoglobin; Hexahydrophthalic anhydride; adducts;

    Abstract : Organic acid anhydrides (OAAs) are low molecular weight chemicals used in the industry for manufacturing of plastics such as epoxy resins. Exposure to these chemicals may lead to symptoms from the eyes and the respiratory tract in form of conjunctivitis, rhinitis and asthma. READ MORE

  4. 2. Protein adducts in plasma as biomarkers of exposure to and risk of organic acid anhydrides

    Author : Seema Rosqvist; Neurokirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GC-MS; IgG; IgE; exposure-response; serum albumin; biological monitoring; Hexahydrophthalic anhydride; methylhexahydrophthalic anhydride; OEL; Occupational health; industrial medicine; Yrkesmedicin; arbetsmiljömedicin;

    Abstract : Organic acid anhydrides (OAAs) are important industrial chemicals but also potent inducers of airways diseases. Many exposed workers develop specific IgE and IgG antibodies. Hexahydrophthalic anhydride (HHPA) and methylhexahydrophthalic anhydride (MHHPA) are two particularly sensitising OAAs. READ MORE

  5. 3. Biomarkers of internal exposure/dose : Methods to quantify adducts to protein and DNA by LC/MS studied with benzo[a]pyrene and isocyanates

    Author : Emelie Westberg; Margareta Törnqvist; Kimmo Peltonen; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; biomarker; PAH; serum albumin; adduct; DNA; isocyanate; miljökemi; Environmental Chemistry;

    Abstract : This thesis focuses on methods for quantification by liquid chromatography/mass spectrometry (LC/MS) of specific biomarkers for internal dose of chemicals which induce toxicity through their electrophilic reactivity. In vivo such compounds are short-lived, and could feasibly be measured as their reaction products (adducts) with biomacromolecules. READ MORE

  6. 4. Amino acids with relevance to health, climate and the environment : Development of mass spectrometric methods

    Author : Javier Zurita; Leopold Ilag; Ulrika Nilsson; Margareta Törnqvist; Natalia Tretyakova; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amino acids; LC MS; fixed-charge derivatization; BMAA; chiral separation; pheromones; arctic aerosols; serum albumin adducts; benzo[a]pyrene diol epoxides; high-resolution MS; Analytical Chemistry; analytisk kemi;

    Abstract : Amino acids play vital roles in health, either in their native form or chemically modified. Some studies have linked certain non-proteinogenic amino acids to neurodegenerative diseases, such as in the case of β-methylaminoalanine (BMAA). READ MORE

  7. 5. Protein Modifications by Low Molecular Weight Chemicals Inducing Airways Diseases

    Author : Marina Jeppsson; Avdelningen för arbets- och miljömedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MSight; hemoglobin human serum albumin; nasal lavage; acrylates; organic acid anhydrides; persulfate; biomarkers adducts; mass spectrometry; MoDetect;

    Abstract : Airways diseases are one of the most common health effects in the western world today. It has been shown that low molecular weight chemicals (LMWC) can cause airways diseases. The mechanisms for these diseases are not well known in most cases. Also, methods for biological monitoring of exposure are not available for many of these LMWC. READ MORE