Search for dissertations about: "serum amyloid A"

Showing result 6 - 10 of 65 swedish dissertations containing the words serum amyloid A.

  2. 6. Heparan Sulfate Dependent Mechanisms of Amyloidosis

    Author : Fredrik Noborn; Jin-ping Li; Ulf Lindahl; Giampaolo Merlini; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Amyloidosis; Heparan sulfate; Transthyretin; Serum amyloid A; Amyloid-beta; lipoproteins; Medical Biochemistry; Medicinsk biokemi;

    Abstract : A common theme in amyloid disorders is the deposition of disease-specific protein aggregates in tissues. Amyloid proteins bind to heparan sulfate (HS), a sulfated glycosaminoglycan, and HS has been found to promote the aggregation process. READ MORE

  4. 7. Deposition and Resolution of AA Amyloid

    Author : Sofia N. Nyström; Gunilla T Westermark; Christoph Röcken; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AA-amyloid; autophagy; resolution; Morphology; cell biology; pathology; Morfologi; cellbiologi; patologi;

    Abstract : Amyloidosis is a group of protein misfolding diseases characterized by extracellulardeposition of fibrillar protein aggregates. Today more than 25 different human amyloidogenicproteins have been identified, causing a variety of pathological conditions that includeAlzheimer’s disease, type 2 diabetes and prion diseases. READ MORE

  5. 8. Antibody-based bead arrays for high-throughput protein profiling in human plasma and serum

    Author : Kimi Drobin; Jochen M. Schwenk; Peter Nilsson; Ulrika Qundos; Angela Silveira; Maria Pernemalm; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; affinity proteomics; immunoassay; antibody microarray; suspension bead array; protein profiling; plasma; serum; biomarker discovery; osteoporosis; inflammatory bowel disease; Crohn s disease; ulcerative colitis; Medical Technology; Medicinsk teknologi;

    Abstract : Affinity-based proteomics utilizes affinity binders to detect target proteins in a large-scale manner. This thesis describes a high-throughput method, which enables the search for biomarker candidates in human plasma and serum. READ MORE

  6. 9. Amyloid-β and lysozyme proteotoxicity in Drosophila : Beneficial effects of lysozyme and serum amyloid P component in models of Alzheimer’s disease and lysozyme amyloidosis

    Author : Liza Bergkvist; Ann-Christin Brorsson; Katarina Kågedal; Jan Johansson; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : In the work presented this thesis, two different conditions that are classified as protein misfolding diseases: Alzheimer's disease and lysozyme amyloidosis and proteins that could have a beneficial effect in these diseases, have been studied using Drosophila melanogaster, commonly known as the fruit fly. The fruit fly has been used for over 100 years to study and better understand fundamental biological processes. READ MORE

  7. 10. Amyloid Beta – Biotherapy Target and Biotechnological Tool

    Author : Sebastian W. Meister; Stefan Ståhl; John Löfblom; Maarten Merkx; KTH; []
    Keywords : Alzheimer’s disease; amyloid beta; blood-brain barrier; green-fluorescent protein; intracellular assays; proteases; protease substrate specificity; protein aggregation; protein engineering.; Bioteknologi; Biotechnology;

    Abstract : Alzheimer’s disease is a progressive neurodegenerative disease characterized primarily by memory impairment and cognitive decline. As of 2020, an estimated 50 million people suffer from Alzheimer’s disease or related dementia and no disease-modifying treatment options are yet approved for clinical practice. READ MORE